Author

A. D. Cook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:plant (other)· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

C. A. Moores· 2 shared J. Atherton· 2 shared R. Tewari· 2 shared A. Akhmanova· 1 shared A. J. Roberts· 1 shared A. Roberts· 1 shared A. Roll-Mecak· 1 shared A. Vemu· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

C. A. Moores

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular mechanism of complement inhibition by the trypanosome receptor ISG65

A. D. Cook, M. Carrington, M. K. Higgins

This paper reveals how the trypanosome receptor ISG65 binds C3b through two sites, acting as a decoy and blocking complement receptors to reduce pathogen clearance.

eLife · Apr 24, 2024Peer-reviewedMicrobiology

Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission

T. Liu, F. Shilliday, A. D. Cook, R. Tewari, C. J. Sutherland, A. J. Roberts, C. A. Moores

This study investigates the molecular mechanism of Plasmodium kinesin-8B, showing its role in male gamete development and parasite transmission through ATP-dependent microtubule interactions and structural adaptations.

bioRxiv · Feb 11, 2022Biochemistry

Molecular mechanism of a parasite kinesin motor and implications for its inhibition

A. D. Cook, A. Roberts, J. Atherton, R. Tewari, M. Topf, C. A. Moores

This study characterizes the molecular mechanism of Plasmodium falciparum kinesin-5 (PfK5) and identifies structural features that could enable selective inhibition of this parasite's motor.

bioRxiv · Jan 26, 2021Biophysics

Structural determinants of microtubule minus end preference in CAMSAP CKK domains

J. Atherton, Y. Luo, S. Xiang, C. Yang, K. Jiang, M. Stangier, A. Vemu, A. D. Cook, S. Wang, A. Roll-Mecak, M. O. Steinmetz, A. Akhmanova, M. Baldus, C. Moores

This study compares human and Naegleria CKK domains to show how structural differences in tubulin conformations enable microtubule minus-end recognition.

bioRxiv · Mar 27, 2019Biophysics