Author

C. Seshadri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:differential expression· 3 Assay:flow cytometry· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

M. S. Aguilar· 3 shared C. L. Day· 2 shared E. D. Layton· 2 shared T. Scriba· 2 shared A. B. Theberge· 1 shared A. Gela· 1 shared A. J. Minnaard· 1 shared A. Sherwood· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

M. S. Aguilar

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

E. Morgun, J. Zhu, S. Almunif, S. Bobbala, M. S. Aguilar, J. Wang, K. Conner, Y. Cui, L. Cao, C. Seshadri, E. A. Scott, C.-R. Wang

This study shows that vaccinating with mycobacterial lipid-loaded nanoparticles induces persistent lipid antigen presence and memory T cell differentiation in mice.

bioRxiv · Mar 7, 2023Immunology

MR1-restricted T cell clonotypes are associated with 'resistance' to M.tuberculosis infection

D. L. Cross, E. D. Layton, K. K. Yu, M. T. Smith, M. S. Aguilar, S. Li, H. Mayanja-Kizza, C. M. Stein, W. H. Boom, T. R. Hawn, P. Bradley, E. Newell, C. Seshadri

The paper identifies MR1-restricted T cell clonotypes associated with resistance to M. tuberculosis infection in a cohort of Ugandan individuals.

bioRxiv · Oct 12, 2022 · PreprintImmunology

Effects of BCG vaccination on donor unrestricted T cells in humans

A. Gela, M. Murphy, K. Hadley, W. Hanekom, H. Boom, J. Johnson, D. Hoft, S. Joosten, T. Ottenhoff, S. Suliman, B. Moody, D. Lewinsohn, M. Hatherill, C. Seshadri, E. Nemes, T. Scriba

This study examines the effects of BCG vaccination on donor unrestricted T (DURT) cells in humans, finding increased frequencies of certain T cell subsets in infants but no changes in others.

bioRxiv · Apr 29, 2021 · PreprintImmunology

CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells.

C. A. James, Y. Xu, M. S. Aguilar, L. Jing, E. D. Layton, M. Gilleron, A. J. Minnaard, T. Scriba, C. L. Day, E. H. Warren, D. M. Koelle, C. Seshadri

This study investigates how CD4 and CD8 co-receptors affect the functional avidity and activation of CD1b-restricted T cells specific for mycobacterial lipid antigens, revealing distinct functional profiles and proliferation patterns.

bioRxiv · Oct 17, 2020Immunology

A modular microscale granuloma model for immune-microenvironment signaling studies in vitro

S. B. Berry, M. S. Gower, X. Su, C. Seshadri, A. B. Theberge

This paper introduces a modular microscale granuloma model to study immune-microenvironment signaling in vitro, showing increased secretion of proinflammatory factors and 3D aggregate formation upon mycobacterial infection.

bioRxiv · Apr 14, 2020Bioengineering

Unbiased Definition Of A Shared T-Cell Receptor Motif Enables Population-Based Studies Of Tuberculosis

W. S. DeWitt, K. K. Quan, D. Wilburn, A. Sherwood, M. Vignali, S. C. De Rosa, C. L. Day, T. J. Scriba, H. S. Robins, W. Swanson, R. O. Emerson, C. Seshadri

The paper identifies a shared T-cell receptor motif specific for a mycobacterial lipid antigen, associated with tuberculosis and independent of host genetic background.

bioRxiv · Apr 3, 2017 · PreprintImmunology