Author

C. L. Drennan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Branstrom· 1 shared A. E. Hamilos· 1 shared A. Gerasyuto· 1 shared A. L. Lukowski· 1 shared B. S. Moore· 1 shared C. Cui· 1 shared C. M. Zimanyi· 1 shared D. A. Born· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperMicrobiology

A. Branstrom

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Oxidative rearrangement of tryptophan to indole nitrile by a single diiron enzyme

S. Adak, N. Ye, L. A. Calderone, R. J. B. Schafer, A. L. Lukowski, M.-E. Pandelia, C. L. Drennan, B. S. Moore

This study identifies a novel diiron enzyme, AetD, that catalyzes the oxidative rearrangement of tryptophan to indole nitrile, revealing a new pathway for nitrile biosynthesis.

bioRxiv · Aug 3, 2023 · PreprintBiochemistry

How ATP and dATP act as molecular switches to regulate enzymatic activity in the prototypic bacterial class Ia ribonucleotide reductase

M. A. Funk, C. M. Zimanyi, G. A. Andree, A. E. Hamilos, C. L. Drennan

This study investigates how ATP and dATP regulate E. coli class Ia ribonucleotide reductase activity through structural analysis of six crystal forms, revealing conformational changes and a novel ATP binding site.

bioRxiv · Jul 31, 2021 · PreprintBiochemistry

Ribonucleotide reductase, a novel target for gonorrhea

J. Narasimhan, S. Letinski, S. Jung, A. Gerasyuto, J. Wang, M. Arnold, G. Chen, J. Hedrick, M. Dumble, K. Ravichandran, T. Levitz, C. Cui, C. L. Drennan, J. Stubbe, G. Karp, A. Branstrom

This study identifies two novel inhibitors of Neisseria gonorrhoeae that target ribonucleotide reductase, showing efficacy against multidrug-resistant strains in a mouse model.

bioRxiv · Nov 19, 2020Microbiology

Isonitrile Formation by a Non-heme Iron(II)-dependent Oxidase/Decarboxylase

N. C. Harris, D. A. Born, W. Cai, Y. Huang, J. Martin, R. Khalaf, C. L. Drennan, W. Zhang

This study identifies a new non-heme iron(II)-dependent enzyme mechanism for isonitrile formation, expanding known biosynthetic pathways.

bioRxiv · Apr 25, 2018Biochemistry