Author

C. L. Duvall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 4 Organism:mouse· 4 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. M. Colazo· 5 shared F. Yu· 4 shared K. A. Hasty· 3 shared S. K. Bedingfield· 3 shared A. M. Hasty· 2 shared B. R. Dollinger· 2 shared D. D. Liu· 2 shared E. N. Hoogenboezem· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersBioengineering

J. M. Colazo

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Author profile →

7 papers

Recent·Most cited

A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine

B. L. Walton, R. Shattuck-Brandt, C. A. Hamann, V. W. Tung, J. M. Colazo, D. D. Brand, K. A. Hasty, C. L. Duvall, J. M. Brunger

This paper develops a synthetic receptor system that enables mesenchymal stromal cells to target and respond specifically to damaged cartilage in osteoarthritis.

bioRxiv · Jan 31, 2024Bioengineering

Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis

J. M. Colazo, E. N. Hoogenboezem, M. C. Keech, N. Francini, V. Shah, F. Yu, J. H. Lo, A. G. Sorets, J. T. McCune, H. Cho, C. R. DeJulius, D. L. Michell, T. Maerz, K. C. Vickers, K. N. Gibson-Corley, , C. L. Duvall

This paper develops an MMP13-targeting siRNA conjugate that preferentially accumulates in arthritic joints, reducing disease markers and outperforming current treatments.

bioRxiv · May 31, 2023 · PreprintBioengineering

ROS-Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair

P. Patil, K. A. Russo, J. T. McCune, A. C. Pollins, M. A. Cottom, B. R. Dollinger, J. M. Colazo, F. Yu, J. R. Martin, M. K. Gupta, N. L. Cardwell, J. M. Davidson, C. M. Thompson, A. Barbul, A. M. Hasty, , C. L. Duvall

This paper develops ROS-degradable polythioketal urethane foams for skin wound healing, showing improved tissue integration and ECM deposition compared to existing materials.

bioRxiv · May 21, 2021 · PreprintBioengineering

Galectin-anchored indoleamine 2,3-dioxygenase suppresses local inflammation

E. Bracho-Sanchez, F. Rocha, S. K. Bedingfield, B. D. Partain, M. A. Brusko, J. M. Colazo, M. M. Fettis, S. A. Farhadi, E. Y. Helm, K. Koenders, A. J. Kwiatkowski, S. L. Macias, A. Restuccia, A. Wanchoo, D. Avram, , B. G. Keselowsky

This paper develops a fusion protein IDO-Gal3 that anchors immunosuppressive enzymes to tissues, effectively suppressing local inflammation in multiple disease models.

bioRxiv · May 7, 2021 · PreprintBioengineering

Kupffer Cell Release of Platelet Activating Factor Drives Dose Limiting Toxicities of Nucleic Acid Nanocarriers

M. A. Jackson, S. S. Patel, F. Yu, M. A. Cottam, E. B. Glass, B. R. Dollinger, E. N. Hoogenboezem, P. Patil, D. D. Liu, I. B. Kelly, S. K. Bedingfield, A. R. King, R. E. Miles, A. M. Hasty, T. D. Giorgio, C. L. Duvall

This paper identifies Kupffer cell release of platelet activating factor (PAF) as a key driver of nanocarrier toxicity and shows that PAFR inhibition prevents dose-limiting toxicities in mice.

bioRxiv · Feb 11, 2020Bioengineering

Matrix-targeted Nanoparticles for MMP13 RNA Interference Blocks Post-Traumatic Osteoarthritis.

S. K. Bedingfield, F. Yu, D. D. Liu, M. A. Jackson, L. E. Himmel, H. Cho, J. M. Colazo, L. J. Crofford, K. A. Hasty, C. L. Duvall

This paper develops MMP13-targeted nanoparticles for RNA interference to treat post-traumatic osteoarthritis, showing significant reduction in MMP13 expression and cartilage damage in mouse models.

bioRxiv · Jan 30, 2020 · PreprintBioengineering

Genetically encoded split luciferase biosensors to measure endosome disruption in real time in live cells

K. V. Kilchrist, J. W. Tierney, C. L. Duvall

This paper develops genetically encoded split luciferase biosensors to detect endosome disruption in live cells, showing improved sensitivity and throughput compared to existing methods.

bioRxiv · Jan 16, 2020Bioengineering