Author

C. L. Holley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Chalem· 1 shared A. E. D. Van Swearingen· 1 shared A. K. Lagendijk· 1 shared A. Porrello· 1 shared B. A. Law· 1 shared B. Hill· 1 shared B. R. Cullen· 1 shared C. J. Stocks· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Chalem

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

L. I. Labzin, K. Y. Chew, K. Eschke, X. Wang, T. Esposito, C. J. Stocks, J. Rae, R. Patrick, H. Mostafavi, B. Hill, T. Yordanov, C. L. Holley, S. Emming, S. Fritzlar, F. L. Mordant, , K. Schroder

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

bioRxiv · Mar 22, 2022 · PreprintImmunology

Snord67 promotes lymph node metastasis and regulates U6-mediated alternative splicing in breast cancer

Y. L. Chao, Y. Zhu, H. J. Wiedner, Y.-H. Tsai, L. Wilkinson, A. Porrello, A. E. D. Van Swearingen, L. A. Carey, J. Giudice, C. L. Holley, C. V. Pecot

This study identifies Snord67 as a regulator of lymph node metastasis in breast cancer by modulating U6-mediated alternative splicing.

bioRxiv · Aug 28, 2020 · PreprintCancer Biology

Extensive epitranscriptomic methylation of A and C residues on murine leukemia virus transcripts enhances viral gene expression

D. Courtney, A. Chalem, H. P. Bogerd, B. A. Law, E. M. Kennedy, C. L. Holley, B. R. Cullen

This study shows that murine leukemia virus (MLV) transcripts have high levels of m6A, m5C, and Nm modifications, which enhance viral replication and gene expression.

bioRxiv · Mar 28, 2019Microbiology