B. Hill

Endothelial c-Src mediates neovascular tuft formation in Oxygen-Induced Retinopathy

This study shows that c-Src is essential for neovascular tuft formation in Oxygen-Induced Retinopathy, as its depletion reduces tuft formation without affecting cell death, proliferation, or adhesion.

Development of a qPCR assay and a LAMP assay for Verticillium longisporum detection and a triplex qPCR assay for simultaneous detection of V. longisporum, Leptosphaeria biglobosa and L. maculans from canola samples

Epigenetic field defect discriminates normal tissues from healthy and tumor-bearing kidneys

The paper identifies DNA methylation alterations in normal kidney tissues that distinguish healthy from tumor-adjacent tissues, suggesting an epigenetic field defect associated with renal cancer risk.

c-Src induced vascular malformations require localised matrix degradation at focal adhesions

This study shows that c-Src activation in endothelial cells causes vascular expansion through focal adhesion signaling and localized matrix degradation, which can be inhibited to prevent abnormal vascular growth.

Cas9+ conditionally immortalized neutrophil progenitors as a tool for genome wide CRISPR screening for neutrophil differentiation and function

This paper introduces a Cas9+ER-Hoxb8 neutrophil progenitor cell line for CRISPR screening to study neutrophil differentiation and function, identifying key genes like Cebpe and the WASH complex.

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

Spatial Transcriptional Mapping of the Human Nephrogenic Program

The paper spatially maps the human nephrogenic program using single-cell RNA sequencing and generates functional gene-networks to identify developmental disease genes and predict new targets.