Author

C. Lutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Bhattacharya· 1 shared A. Castor· 1 shared A. Ho· 1 shared A. Marciniak-Czochra· 1 shared A. Moises da Silva· 1 shared A. P. Drenth· 1 shared A. Schuh· 1 shared A. Trumpp· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Bhattacharya

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Complex genotype-phenotype relationships shape the response to treatment of Down Syndrome Childhood Acute Lymphoblastic Leukaemia

C. Lutz, V. A. Turati, R. Clifford, P. S. Woll, T. Stiehl, A. Castor, S. A. Clark, H. Ferry, V. Buckle, A. Trumpp, A. Ho, A. Marciniak-Czochra, J. Herrero, A. Schuh, S. E. W. Jacobsen, T. Enver

This study investigates genotype-phenotype relationships in Down Syndrome ALL, showing that genetic and phenotypic heterogeneity influences treatment response and relapse through clonal competition.

bioRxiv · Feb 6, 2022Cancer Biology

MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

D. Zimmerli, C. S. Brambillasca, F. Talens, J. Bhin, A. Bhattacharya, S. E. P. Joosten, A. Moises da Silva, M. D. Wellenstein, K. Kersten, M. de Boo, M. Roorda, L. Henneman, R. de Bruijn, S. Annunziato, E. van der Burg, , J. Jonkers

This study shows MYC overexpression in TNBC reduces immune cell infiltration and interferon signaling, contributing to immune evasion and poor response to immunotherapy.

bioRxiv · Feb 24, 2021 · PreprintCancer Biology

Pseudomonas aeruginosa isolates co-incubated with Acanthamoeba castellanii exhibit phenotypes similar to chronic cystic fibrosis isolates

W. Leong, C. Lutz, J. Williams, Y. H. Poh, B. K. Y. Yeo, C. Chua, S. A. Rice, M. Givskov, M. Sanderson-Smith, D. McDougald

This paper shows that Pseudomonas aeruginosa co-incubated with Acanthamoeba castellanii develops genetic and phenotypic traits similar to chronic cystic fibrosis isolates, suggesting similar selection pressures from different host environments.

bioRxiv · Feb 25, 2020 · PreprintMicrobiology