C. Mycroft-West

This study shows that various glycosaminoglycans, beyond heparin, can induce conformational changes in the SARS-CoV-2 Spike S1 receptor binding domain.

This study shows low molecular weight heparins induce conformational changes in SARS-CoV-2 Spike RBD, suggesting potential for repurposing as antiviral agents.

This study shows heparin inhibits SARS-CoV-2 invasion by binding to the Spike protein's RBD and inducing conformational changes, with structural features of heparin playing a key role.

This paper proposes using ATR-FTIR spectroscopy with multivariate analysis to rapidly and cost-effectively monitor heparin purity and detect contaminants.

This study identifies a marine-derived glycosaminoglycan extract from Portunus pelagicus that inhibits BACE1 with reduced anticoagulant activity compared to mammalian heparin.