D. Su

Cortical potentials evoked by stimulation of cervical vagus vs. auricular nerve: a comparative, parametric study in nonhuman primates

This study compares cortical potentials evoked by cervical vagus and trans-auricular nerve stimulation in nonhuman primates, finding that cVNS produces more robust responses with distinct parameter effects.

Membrane potential mediates the cellular response to mechanical pressure

This study shows that membrane potential mediates cellular responses to mechanical pressure by regulating cell growth, proliferation, and elimination through Hippo and MAPK pathways.

Strong immunogenicity & protection in mice with PlaCCine: A COVID-19 DNA vaccine formulated with a functional polymer

This study evaluates a DNA vaccine, PlaCCine, showing strong immunogenicity and protection in mice against SARS-CoV-2 variants.

Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

This study shows high-intensity ultrasound increases anti-inflammatory EV secretion from skeletal myotubes by raising intracellular calcium levels, which reduces pro-inflammatory gene expression in macrophages.

Crystal structure of monkeypox H1 phosphatase, an Antiviral Drug Target

The paper determines the crystal structure of monkeypox H1 phosphatase, revealing its dimeric form and active site, which informs antiviral drug development.

Protection from Omicron and other VOCs by Bivalent S-Trimer COVID-19 Vaccine

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.

Acetyltransferases GCN5 and PCAF are required for B lymphocyte maturation in mice

This study shows that GCN5 and PCAF are essential for B cell maturation and class switch recombination in mice.

Tomato SlBES1.8 influences leaf morphogenesis by mediating gibberellin metabolism and signaling

This study identifies SlBES1.8 as a tomato transcription factor that promotes leaf simplification by modulating gibberellin metabolism and signaling.

The tetrameric assembly of 2-aminomuconic acid dehydrogenase is a functional requirement of cofactor NAD+ binding

This paper identifies the tetrameric assembly of AmnC as essential for NAD+ binding and enzymatic activity in 2-aminophenol metabolism.

Structural insight into molecular inhibitory mechanism of InsP6 on African Swine Fever Virus mRNA-decapping enzyme g5Rp

The paper reports the structure of ASFV g5Rp and its complex with InsP6, revealing how InsP6 inhibits mRNA decapping by competing with RNA binding sites.

Engineered small extracellular vesicles as a FGL1/PD-L1 dual-targeting delivery system for alleviating immune rejection

This study develops engineered small extracellular vesicles targeting FGL1 and PD-L1 to suppress immune rejection in transplantation by inhibiting T cell activation and improving graft survival.

Broad neutralization against SARS-CoV-2 variants induced by a modified B.1.351 protein-based COVID-19 vaccine candidate

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

Cryo-EM structure of S-Trimer, a subunit vaccine candidate for COVID-19

The paper determines the Cryo-EM structures of S-Trimer variants for COVID-19 vaccine development, showing they adopt a tightly closed conformation similar to the full-length S protein.

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction

This paper shows that pixatimod inhibits SARS-CoV-2 by disrupting the Spike-ACE2 interaction, demonstrating its potential as an anti-COVID-19 therapeutic.

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain.

This study shows that various glycosaminoglycans, beyond heparin, can induce conformational changes in the SARS-CoV-2 Spike S1 receptor binding domain.

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins.

This study shows low molecular weight heparins induce conformational changes in SARS-CoV-2 Spike RBD, suggesting potential for repurposing as antiviral agents.

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin.

This study shows heparin inhibits SARS-CoV-2 invasion by binding to the Spike protein's RBD and inducing conformational changes, with structural features of heparin playing a key role.

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding.

The paper shows that SARS-CoV-2 Spike S1 RBD undergoes a conformational change when bound to heparin, suggesting potential for heparin as a therapeutic.

C17orf53 defines a novel pathway involved in inter-strand crosslink repair

This study identifies C17orf53 as a novel gene involved in inter-strand crosslink repair, showing its role in DNA replication and repair factor loading.

Probiotic strains improve high-fat diet-induced hypercholesterolemia through modulating gut microbiota in ways different from atorvastatin

This study compares the hypocholesterolemia effects of four probiotic strains with atorvastatin in a high-fat diet model, showing probiotics are less effective but alter gut microbiota differently.

The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis

This study identifies extracellular heparin-binding proteins (HBPs) in normal and acute pancreatitis mouse pancreas and plasma, revealing their roles in homeostasis and inflammation.

Bimodal Regulation of the PRC2 Complex by USP7 Underlies Melanomagenesis

This study identifies USP7's dual role in stabilizing EZH2 and facilitating PRC2 chromatin loading, promoting melanoma progression and correlating with poor patient prognosis.