M. Lima

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

Highly pathogenic avian influenza H5N1 virus infections in pinnipeds and seabirds in Uruguay: a paradigm shift to virus transmission in South America

The paper identifies clade 2.3.4.4b H5N1 influenza strains in pinnipeds and seabirds in Uruguay, suggesting mammal-to-mammal and seabird transmission routes in South America.

Fecal Virome of Coendou spinosus (Paraguaian Hairy Dwarf Porcupine)

The study sequenced the fecal virome of Brazilian porcupines, identifying 41 viral families and highlighting potential zoonotic agents.

1000 years of population, warfare, and climate change in pre-Columbian societies of the Central Andes

The paper uses population dynamic models to analyze how climate change and warfare influenced population trends in pre-Columbian Central Andes societies over a millennium.

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain.

This study shows that various glycosaminoglycans, beyond heparin, can induce conformational changes in the SARS-CoV-2 Spike S1 receptor binding domain.

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins.

This study shows low molecular weight heparins induce conformational changes in SARS-CoV-2 Spike RBD, suggesting potential for repurposing as antiviral agents.

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin.

This study shows heparin inhibits SARS-CoV-2 invasion by binding to the Spike protein's RBD and inducing conformational changes, with structural features of heparin playing a key role.

Heparan sulfate structure is influenced by the ER-Golgi dynamics of its modifying enzymes

This study shows that changes in the localization of HS-modifying enzymes in the ER-Golgi pathway influence HS structure, highlighting the role of vesicular trafficking in HS biosynthesis.

Chromatin structure changes in Daphnia populations upon exposure to environmental cues - or - The discovery of Wolterecks \"Matrix\"

The paper revisits Woltereck's Matrix hypothesis by showing chromatin structure changes in Daphnia exposed to environmental cues using a new ATAC-seq method.

A glycosaminoglycan extract from Portunus pelagicus inhibits BACE1, the β secretase implicated in Alzheimer’s disease

This study identifies a marine-derived glycosaminoglycan extract from Portunus pelagicus that inhibits BACE1 with reduced anticoagulant activity compared to mammalian heparin.