PathologybioRxivPreprint
Therapeutic activation of endothelial sphingosine 1-phosphate receptor-1 by chaperone-bound S1P suppresses proliferative retinal vasculopathy
C. Niaudet, B. Jung, A. Kuo…·T. Hla
The paper shows that activating endothelial S1PR1 with HDL-bound S1P or a Gi-biased agonist suppresses neovascular tufts in retinopathy models.
DOI 10.1101/2022.06.14.496172