C. Niehrs

The paper shows that primary cilia transduce WNT signals independently of β-catenin by regulating PP1 activity through the WNT/GSK3 pathway.

This paper introduces ROTACs, signaling-incompetent R-spondin chimeras that target transmembrane proteins for degradation, demonstrating efficacy against PD-L1 in melanoma cells.

The paper shows DDX proteins act as nucleotide exchange factors for CK22, enhancing kinase activity and revealing a new regulatory mechanism for protein kinases.