C. O'Brien

Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation

The paper identifies osteomodulin as a promoter of breast cancer bone metastasis through CDK1 activation using proteomics and phosphoproteomics analysis of patient-derived tumors.

Modeling Cystic Fibrosis Chronic Infection Using Engineered Mucus-like Hydrogels

This study develops mucus-like hydrogels to model cystic fibrosis airway infections and finds that antibiotic resistance depends on both hydrogel properties and culture conditions.

Inhibition of potassium ion channels reduces Semliki Forest virus genome replication

This study shows that K+ channel inhibitors reduce SFV replication and cytotoxicity in vitro by disrupting an early post-entry step, suggesting potential for antiviral repurposing.

Global health open-source goggles for fluorescence-guided surgery

The paper develops a low-cost, open-source, wearable fluorescence-guided surgery system to improve access in low-resource settings.

Phylogenetic background and habitat drive the genetic diversification of Escherichia coli

The paper studies the genetic diversification of Escherichia coli across different habitats and phylogenetic groups using a large dataset of non-clinical isolates from Australia.

Tbx2a modulates switching of opsin gene expression

The paper identifies Tbx2a as a transcription factor that switches LWS and RH2 opsin expression in African cichlid fishes by promoting one while repressing the other.