J. Watson

Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation

The paper identifies osteomodulin as a promoter of breast cancer bone metastasis through CDK1 activation using proteomics and phosphoproteomics analysis of patient-derived tumors.

The impacts of contemporary logging after 250 years of deforestation and degradation on forest-dependent threatened species

This study quantifies historical and contemporary impacts of deforestation and logging on forest-dependent threatened species in New South Wales, showing significant habitat loss and degradation.

A report card methodology to showcase progress towards threatened species recovery

This paper introduces a report card methodology to assess progress in threatened species recovery in Australia, revealing poor performance across key indicators.

A statistical censoring approach accounts for hook competition in abundance indices from longline surveys

The paper introduces a statistical censoring method to correct for hook competition bias in longline survey abundance indices, showing significant improvements over existing methods.

Spatially Resolved Phosphoproteomics Reveals Fibroblast Growth Factor Receptor Recycling-driven Regulation of Autophagy and Survival

The paper uses spatially resolved phosphoproteomics to show FGFR2b recycling activates mTOR and ULK1, suppressing autophagy and promoting cell survival in cancer cells.

Shared hotspot mutations in spontaneously arising cancers position dog as an unparalleled comparative model for precision therapeutics

This study identifies shared hotspot mutations in canine and human cancers, highlighting dogs as a valuable model for precision cancer therapeutics.

ATM phosphorylates PP2A subunit A resulting in nuclearexport and spatiotemporal regulation of the DNA damageresponse

This study shows ATM phosphorylates PR65 at S401, regulating DDR by controlling PR65 nuclear-cytoplasmic shuttling and affecting DSB repair and cell survival.

The global rarity of intact coastal regions

The paper assesses global coastal regions' anthropogenic pressures by integrating human footprint and marine impact maps, finding that most are heavily impacted and protected areas are often under high pressure.

Reciprocal Priming between RTKs at Recycling Endosomes Orchestrates Cellular Signaling Outputs

The paper identifies reciprocal priming between FGFRs and EGFR at recycling endosomes that coordinates signaling outputs in breast cancer cells.

DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity

This study identifies DGAT1 as an oncoprotein that enables cancer cells to accumulate fatty acids while avoiding lipotoxicity, promoting melanoma formation.

Deforestation and bird habitat loss in Colombia

This study assesses the impact of deforestation on bird habitats in Colombia, finding widespread habitat loss and projecting increased threat levels by 2040.

Mapping the unique and shared functions of oncogenic KRAS and RIT1 with proteome and transcriptome profiling

This study compares proteomic and transcriptomic profiles of KRAS and RIT1 mutant lung cells to identify shared and divergent functions in oncogenic signaling.

Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence

This paper shows that Shigella sonnei's O-antigen mediates neutrophil tolerance and increases dysentery incidence in zebrafish, suggesting O-antigen as a therapeutic target.

Reconciling global priorities for conserving biodiversity habitat

The paper identifies high-value biodiversity habitats by integrating habitat condition and species assemblage data, finding that 18.6% of these areas are currently protected.

Shigella sonnei O-antigen inhibits internalisation, vacuole escape and inflammasome activation

This study shows that S. sonnei's O-antigen reduces macrophage uptake and vacuole escape, leading to less pyroptosis compared to S. flexneri.