J. Parsons

Differential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases

This study identifies six prolyl-4 hydroxylases in mosses and characterizes their substrate specificity, structural features, and functional roles in proline hydroxylation and O-glycosylation.

Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation

The paper identifies osteomodulin as a promoter of breast cancer bone metastasis through CDK1 activation using proteomics and phosphoproteomics analysis of patient-derived tumors.

Multifactorial analysis of terminator performance on heterologous gene expression in Physcomitrella

The paper characterizes Physcomitrella 3UTRs to identify effective terminators for gene expression, showing promoters have a greater impact than terminators.

Structural modelling of human complement FHR1 and two of its synthetic derivatives provides insight into their in-vivo functions

This study models the structure of FHR1 and its derivatives using AlphaFold2 and AlphaFold-Multimer to understand their interactions with complement components and their potential as therapeutic agents.

Factors governing attachment of Rhizobium leguminosarum to legume roots

This study identifies 115 proteins required for Rhizobium leguminosarum attachment to pea roots under varying pH conditions, revealing complex mechanisms and no single essential protein for alkaline attachment.

Unexpected arabinosylation after humanization of plant protein N-glycosylation

This paper reports the unexpected arabinosylation observed during humanization of plant protein N-glycosylation, highlighting its implications for biopharmaceutical safety.

Process engineering of biopharmaceutical production in moss bioreactors via model-based description and evaluation of phytohormone impact

The paper investigates how phytohormone auxin enhances recombinant protein production in moss bioreactors and proposes a kinetic model for process optimization.

A synthetic protein as efficient multitarget regulator against complement over-activation

The paper designs a synthetic protein, MFHR13, that enhances complement regulation and shows improved therapeutic activity compared to existing treatments.

Reciprocal Priming between RTKs at Recycling Endosomes Orchestrates Cellular Signaling Outputs

The paper identifies reciprocal priming between FGFRs and EGFR at recycling endosomes that coordinates signaling outputs in breast cancer cells.

Stable Protein Sialylation in Physcomitrella

This study demonstrates stable N-glycan sialylation in genetically modified Physcomitrella patens by expressing mammalian enzymes and modifying galactosyltransferase genes.

Biodiversity and niche partitioning in an anaerobic benzene degrading culture

The paper investigates biodiversity and niche partitioning in a 15-year-old anaerobic benzene-degrading bioreactor, showing that species interactions maintain high diversity through trophic levels.