N. Ali

Jagged-1+ Skin Tregs Modulate the Innate Immune Response to Wound Healing

This study shows that Jag1-expressing skin Tregs delay wound closure by reducing neutrophil recruitment but do not affect other immune cell populations or hair regeneration.

Jagged-1+ Tregs Mediate Lymphatic Remodeling in Tumour-Draining Lymph Nodes

This study shows that Jag1-expressing regulatory T cells (Tregs) in tumor-draining lymph nodes (tdLNs) are essential for lymphatic remodeling and niche formation during melanoma progression.

Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation

The paper identifies osteomodulin as a promoter of breast cancer bone metastasis through CDK1 activation using proteomics and phosphoproteomics analysis of patient-derived tumors.

Early life regulatory T cells modulate PPAR-gamma dependent skin pigmentation

The paper shows that early life regulatory T cells (ETregs) regulate PPAR-gamma signaling in hair follicles, which is essential for melanocyte stem cell-mediated skin pigmentation.

Recyclable CRISPR/Cas9 mediated gene disruption and deletions in Histoplasma

This paper develops a CRISPR/Cas9 system for efficient targeted gene disruption in Histoplasma, enabling high-efficiency mutagenesis and deletion of specific genes.

Immunomodulatory effects of Simvastatin in Toll-like receptor-2 stimulated Rheumatoid arthritis synoviocytes

This study shows simvastatin induces apoptosis in rheumatoid arthritis synoviocytes by upregulating BNIP3 and inhibiting Akt, while increasing IL-6 and antioxidant gene expression.

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

This study uses CRISPR screening to identify C3aR as critical for macrophage capture of fungi, revealing a novel role in fungal pathogen recognition.

Identification of marker-trait associated SNPs for fruit weight and plant height in a wild and domesticated jujube fruit tree (Ziziphus spp.) collection using genotyping-by-sequencing

Mineral crystal thickness in calcified cartilage and subchondral bone in healthy and osteoarthritic knees

The paper measures mineral crystal thickness in calcified cartilage and subchondral bone of healthy and osteoarthritic knees, finding increased thickness in the unloaded lateral compartment and decreased thickness in subchondral bone with OA severity.

Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation induced tissue damage

This study investigates the role of fibroblast lineages and immune cells in dermal repair after UV radiation damage, finding that T cells support fibroblast survival and that COX-2 inhibition prevents fibroblast depletion.

Two pectate lyases from Caldicellulosiruptor bescii with the same CALG domain had distinct properties on plant biomass degradation

This paper characterizes two pectate lyases from Caldicellulosiruptor bescii, showing distinct degradation properties and roles of their CALG domain in plant biomass breakdown.

Trisk95 as Novel Skin Mirror for Normal and Diabetic Systemic Glucose Level

This study identifies Trisk95 as a glucose-responsive biomarker in skin cells that mirrors systemic glucose levels, offering a potential non-invasive monitoring approach for diabetes.

Bright split red fluorescent proteins with enhanced complementation efficiency for the tagging of endogenous proteins and visualization of synapses

The paper improves split fluorescent proteins for better brightness and develops a new synaptic marker for visualizing synapses in living animals.