P. A. Sigala

This study investigates the function of two cytochrome c homologs in the mitochondrial electron transport chain of malaria parasites, revealing that one is essential while the other has unique structural properties and is not required for blood-stage growth.

This study identifies a critical role for isoprenoids in apicoplast biogenesis in malaria parasites, showing that IPP and polyprenols are essential for apicoplast membrane fluidity and inheritance.

This paper identifies a divergent acyl carrier protein in Plasmodium that couples mitochondrial Fe-S cluster biogenesis to the electron transport chain, independent of fatty acid synthesis.

This study shows doxycycline kills malaria parasites via apicoplast-specific mechanisms at high concentrations, with distinct metal-dependent and delayed-death effects in different cycles.