Direct antiviral activity of interferon stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cells
D. Holthaus, A. Vasou, C. G. Bamford, J. Andrejeva, C. Paulus, R. E. Randall, J. McLauchlan, D. J. Hughes
The paper shows that ISG15-deficient cells are resistant to paramyxovirus infection due to direct antiviral activity of ISGs, but prolonged IFN treatment causes resistance through translational inhibition.
bioRxiv · Dec 12, 2019Immunology