M. Jiang

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

OsAAI1-OsMADS25 module orchestrates root morphogenesis by fine-tuning IAA in drought stressed rice

This study shows that OsAAI1 and OsMADS25 regulate rice root growth and drought resistance by modulating IAA levels and downstream gene expression.

The gut microbiota is essential for Trichinella spiralis-evoked suppression of colitis

This study shows that Trichinella spiralis infection protects against colitis in mice by altering the gut microbiota, increasing SCFA-producing bacteria, and enhancing goblet cell differentiation and IL-10 levels.

The Class III peroxidase OsPrx20 is a key regulator of stress response and growth in rice

This study identifies OsPrx20 as a key regulator of stress response and growth in rice, showing its dual role in osmotic stress tolerance and blast resistance.

Caspase cleavage of Influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production

This study shows that caspase cleavage of the Influenza A virus M2 protein disrupts its interaction with LC3, reducing virion production.

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

Deciphering the rule of antigen-antibody amino acid interaction

The paper classifies antigen-antibody amino acid mutations into four types and identifies rules governing immune escape and mutation effects.

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

Dissecting signaling regulators driving AXL-mediated bypass resistance and associated phenotypes by phosphosite perturbations

The paper uses phosphosite perturbations to identify signaling pathways driving AXL-mediated erlotinib resistance in lung cancer.

Live soil ameliorated the negative effects of biodegradable but not non-biodegradable microplastics on the growth of plant communities

The paper tests how biodegradable and non-biodegradable microplastics affect plant communities in live vs. sterilized soil, finding live soil mitigates biodegradable plastic effects but both types suppress diversity more in live soil.

Harnessing Landrace Diversity Empowers Wheat Breeding for Climate Resilience

This study uses landrace diversity in wheat to identify genetic resources for climate resilience and improved traits, providing a framework for crop improvement.

The wheat powdery mildew resistance gene Pm4 also confers resistance to wheat blast

The paper identifies that the wheat resistance gene Pm4 confers resistance to wheat blast caused by Magnaporthe oryzae, highlighting its importance for developing resistant cultivars in affected regions.

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

This study examines the long-term microbial changes in desert soil during ecological restoration, finding shifts in community structure, functional diversity, and biogeochemical cycles over 17 years.

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

Latitudinal scaling of aggregation with abundance and its consequences for coexistence in species rich forests

The paper examines latitudinal patterns in species aggregation and abundance, showing how these patterns affect coexistence in forests and introduces a framework to model their impact on extinction risk.

Latitude influences stability via stabilizing mechanisms in naturally-assembled forest ecosystems at different spatial grains

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

Divergent microbial structure still results in convergent microbial function during arrested anaerobic digestion of food waste at different hydraulic retention times

This study shows that different microbial structures in anaerobic digesters with varying hydraulic retention times result in similar VFA production due to functional redundancy.

The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

Contact Stiffness Provides a Unified Frame of Reference for Understanding the Effects of Extracellular Matrix Mechanics on Cell Behaviors

The paper introduces contact stiffness as a framework to quantify how ECM mechanics influence cell behaviors, showing its correlation with YAP activity and stem cell differentiation.

A latitudinal pattern of plant leaf-associated bacterial community assembly

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity

The paper shows that mouse and human kidneys produce biologically active vasopressin in response to NaCl-induced hypertonicity and water restriction.

Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.1 and BA.2 variants and their mouse origins

This study investigates the structural and biochemical features of Omicron BA.1 and BA.2 variants, showing increased infectivity and mouse ACE2 binding compared to wildtype, suggesting a potential human-cat-mouse-human transmission cycle.

Alveolar regeneration following viral infection is independent of tuft cells

This study shows that alveolar regeneration after viral infection occurs independently of tuft cells, with ectopic basal progenitor cells generating alveolar epithelial cells through distinct differentiation paths.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant Mycobacterium marinum

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

Climate shapes flowering periods across plant communities

This study examines how climate influences flowering periods across plant communities in Australia, finding that temperature and precipitation patterns explain 29% of variation in community flowering period lengths.

Early life exposure to high fructose diet induces metabolic dysregulation associated with sex-specific cognitive impairment in adolescent rats.

This study shows that early life high fructose exposure in rats leads to metabolic dysregulation and male-specific cognitive impairments in adolescence.

Analysis of rhizosphere bacterial diversity of Angelica dahurica var. formosana based on different experimental sites and varieties (strains)

This study analyzes rhizosphere bacterial diversity of Angelica dahurica var. formosana across different sites and varieties, finding stable communities and key taxa linked to yield and quality.

Deep Learning-Based Approaches for Decoding Motor Intent from Peripheral Nerve Signals

This paper compares deep learning and machine learning approaches for decoding motor intent from nerve signals, finding that deep learning offers better accuracy with large data while machine learning is more efficient with smaller datasets.