Author

J. McLauchlan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 6 Assay:bulk RNA-seq· 3 Assay:proteomics· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Bamford· 3 shared A. Vasou· 2 shared C. G. Bamford· 2 shared C. G. G. Bamford· 2 shared D. J. Hughes· 2 shared E. Aranday-Cortes· 2 shared J. Andrejeva· 2 shared K. C. Garcia· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersImmunology

C. Bamford

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A human and rhesus macaque interferon-stimulated gene screen reveals ARHGEF3/XPLN as an antiviral gene against hepatitis C virus and other flaviviruses

C. Bamford, E. Aranday-Cortes, R. Sanchez-Velazquez, C. Mullan, A. Kohl, A. H. Patel, S. J. Wilson, J. McLauchlan

This study identifies ARHGEF3/XPLN as an antiviral gene that inhibits HCV and flavivirus replication in both humans and rhesus macaques through a genome-wide screen.

bioRxiv · May 12, 2022 · PreprintMicrobiology

Conserved induction of distinct antiviral signalling kinetics by primate interferon lambda 4 proteins

C. Guo, D. Reuss, J. D. Coey, S. Sukumar, B. Lang, J. McLauchlan, S. Boulant, M. L. Stanifer, C. Bamford

This study shows that IFN{lambda}4 induces distinct antiviral signalling kinetics compared to IFN{lambda}1 and 3 in human hepatocyte and intestinal cells, with these effects conserved in non-human primates.

bioRxiv · Sep 15, 2021Immunology

A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling

A. Vasou, K. Nightingale, V. Cetkovska, J. Scheler, C. G. Bamford, J. Andrejeva, U. Schwarz-Linek, R. E. Randall, J. McLauchlan, M. P. Weekes, D. Bogunovic, D. J. Hughes

The paper identifies a new function of ISG15 in stabilizing USP18 through non-covalent interactions, revealing a mechanism that controls type I IFN signalling.

bioRxiv · Jun 1, 2021 · PreprintImmunology

An interferon lambda 4-associated variant in the hepatitis C virus RNA polymerase affects viral replication in infected cells

C. G. G. Bamford, J. McLauchlan

The paper examines IFNL4-associated variants in HCV NS5B RNA polymerase and shows they modestly affect viral replication, both with and without IFNλ4.

bioRxiv · Jun 22, 2020Microbiology

Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure

D. A. Smith, A. Magri, R. Bowden, N. Chaturvedi, J. Fellay, J. McLauchlan, G. R. Foster, W. L. Irving, STOP-HCV Consortium, P. Simmonds, V. Pedergnana, E. Barnes, M. A. Ansari

This study identifies three HCV polymorphisms in NS2 and NS3 proteins associated with sofosbuvir treatment failure using whole genome sequencing of 507 patients.

bioRxiv · May 5, 2020Microbiology

Direct antiviral activity of interferon stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cells

D. Holthaus, A. Vasou, C. G. Bamford, J. Andrejeva, C. Paulus, R. E. Randall, J. McLauchlan, D. J. Hughes

The paper shows that ISG15-deficient cells are resistant to paramyxovirus infection due to direct antiviral activity of ISGs, but prolonged IFN treatment causes resistance through translational inhibition.

bioRxiv · Dec 12, 2019Immunology

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

K. Pervolaraki, S. Rastgou Talemi, D. Albrecht, F. Bormann, C. Bamford, J. Mendoza, K. C. Garcia, J. McLauchlan, T. Höfer, M. L. Stanifer, S. Boulant

This paper shows that type I and III interferons induce interferon stimulated genes with different kinetics, and these differences are intrinsic to the signaling pathways, not receptor abundance.

bioRxiv · Oct 19, 2018Immunology

A Polymorphic Residue That Attenuates the Antiviral Potential of Interferon Lambda 4 in Hominid Lineages

C. G. G. Bamford, E. Aranday-Cortes, I. Cordeiro Filipe, S. Sukumar, D. Mair, A. da Silva Filipe, J. L. Mendoza, K. C. Garcia, S. Fan, S. A. Tishkoff, J. McLauchlan

The paper identifies a polymorphic residue in IFN{lambda}4 that reduces its antiviral activity in humans compared to other hominids, contributing to differences in HCV clearance.

bioRxiv · Mar 26, 2018Immunology