Author

D. J. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Vasou· 2 shared C. G. Bamford· 2 shared J. Andrejeva· 2 shared J. McLauchlan· 2 shared R. E. Randall· 2 shared A. Whitehouse· 1 shared C. Paulus· 1 shared D. Bogunovic· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

A. Vasou

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Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 10, 2021

Kv1.3 induced hyperpolarisation and Cav3.2-mediated calcium entry are required for efficientKaposi's sarcoma-associated herpesvirus lytic replication

H. Carden, M. Dallas, D. J. Hughes…·A. Whitehouse

The paper identifies Kv1.3 and Cav3.2 ion channels as essential for KSHV lytic replication by promoting Ca2+ influx and NFAT activation.

DOI 10.1101/2021.09.10.459757

humanexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintJun 1, 2021

A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling

A. Vasou, K. Nightingale, V. Cetkovska…·D. J. Hughes

The paper identifies a new function of ISG15 in stabilizing USP18 through non-covalent interactions, revealing a mechanism that controls type I IFN signalling.

DOI 10.1101/2021.06.01.446527

humanproteomics

𝕏 PostBluesky

ImmunologybioRxivDec 12, 2019

Direct antiviral activity of interferon stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cells

D. Holthaus, A. Vasou, C. G. Bamford…·D. J. Hughes

The paper shows that ISG15-deficient cells are resistant to paramyxovirus infection due to direct antiviral activity of ISGs, but prolonged IFN treatment causes resistance through translational inhibition.

DOI 10.4049/jimmunol.1901472

humanbulk RNA-seq

𝕏 PostBluesky