Author

N. Martinez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Cancer Biology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Bahrami· 1 shared A. Cayuela· 1 shared A. Cregger· 1 shared A. Larbi· 1 shared A. Lee· 1 shared A. R. Tannenbaum· 1 shared A. Shelat· 1 shared A. Singhal· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperCancer Biology

A. Bahrami

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Recombinant chimeric Horsepox Virus (TNX-801) is attenuated relative to Vaccinia Virus Strains in Human Primary Cell Lines and in Immunocompromised Mice

S. Trefry, C. Raney, A. Cregger, N. Martinez, B. Layton, R. Enamorado, D. Gohegan, T. Moulaei, N. Ziolkowska, S. Goebel, S. Lederman, S. Bavari, F. Nasar

This study compares the attenuation of TNX-801, a recombinant chimeric Horsepox virus, to VACV-based vaccines in cell lines and mice, showing TNX-801 is significantly more attenuated.

bioRxiv · Oct 25, 2023 · PreprintMicrobiology

Sex-biased expression is associated with chromatin state in D. melanogaster and D. simulans

A. V. Nanni, N. Martinez, R. Graze, J. R. B. Newman, V. Jain, S. Vlaho, S. Signor, S. V. Nuzhdin, R. Renne, L. McIntyre

The paper investigates the association between chromatin state and sex-biased gene expression in D. melanogaster and D. simulans, finding conserved patterns and species-specific differences.

bioRxiv · Jan 13, 2023 · PreprintEvolutionary Biology

Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming

B. Soler Palacios, R. Villares, P. Lucas, J. M. Rodriguez Frade, A. Cayuela, J. G. Piccirillo, D. Delgado Gestoso, C. Risco, F. Corrales, C. O. S. Sorzano, N. Martinez, J. J. Conesa, F. J. Iborra, M. Mellado

This study shows growth hormone remodels mitochondrial structure and promotes metabolic reprogramming in inflammatory macrophages.

bioRxiv · Aug 22, 2022Immunology

ImPartial: Partial Annotations for Cell Instance Segmentation

N. Martinez, G. Sapiro, A. R. Tannenbaum, T. J. Hollmann, S. Nadeem

ImPartial improves cell instance segmentation in noisy multiplex spatial images using partial annotations and self-supervised imputation, showing effectiveness on cancer datasets.

bioRxiv · Jan 20, 2021 · PreprintBioengineering

Interrogation of SLFN11 in pediatric sarcomas uncovers an unexpected biological role and a novel therapeutic approach to overcoming resistance to replicative stress

J. Gartrell, M. Mellado-Lagarde, N. Martinez, M. Clay, A. Bahrami, N. Sahr, A. Sykes, K. Blankenship, L. Hoffmann, J. Xie, H. P. Cho, N. Twarog, M. Connelly, K.-K. Yan, J. Yu, , A. Shelat

This study investigates SLFN11's role in pediatric sarcomas, finding it promotes tumor growth and resistance to DNA-damaging agents, which can be overcome by BCL-XL inhibition.

bioRxiv · Nov 5, 2020 · PreprintCancer Biology

Metformin enhances anti-mycobacterial responses by educating immunometabolic circuits of CD8+ T cells

J. Bohme, N. Martinez, S. Li, A. Lee, M. Marzuki, A. Tizazu, D. Ackart, J. Frenkel, A. Todd, E. Lachmandas, J. Lum, F. Shihui, T. P. Ng, B. Lee, A. Larbi, , A. Singhal

This study shows metformin improves anti-mycobacterial responses by enhancing metabolic and functional properties of CD8+ T cells in mice and humans.

bioRxiv · Aug 26, 2020Immunology