G. Hamilton

Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip

This study develops a human Proximal Tubule Kidney-Chip to assess renal transporter-based drug-drug interactions and demonstrates its ability to predict clinical outcomes and clearance values.

Cell-type specific transcriptional networks in root xylem adjacent cell layers

The paper identifies cell-type specific transcriptional networks in Arabidopsis root xylem-adjacent layers using promoter tagging and chromatin analysis, revealing ZAT6's role in regulating Na+ accumulation.

Effective Computational Framework for Pre-Interventional Planning of Peripheral Arteriovenous Malformations with In Vivo and In Vitro Validation

This paper develops a computational framework to simulate AVM haemodynamics and predict embolisation outcomes, validated with clinical and experimental data.

Modeling alcoholic liver disease in a human Liver-Chip

This paper develops a human ALD Liver-Chip to model alcohol-induced liver injury, showing it recapitulates FLD markers and enables multimodal profiling of clinically relevant endpoints.

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

This paper develops a micro-engineered Airway Lung-Chip model that replicates viral-induced asthma exacerbation features and evaluates immunomodulatory therapies.

Liver-Chip: Reproducing Human and Cross-Species Toxicities

The paper designs Liver-Chips for rat, dog, and human to replicate species-specific liver toxicities and predict human relevance.

Trypanosoma brucei ribonuclease H2A is an essential enzyme that resolves R-loops associated with transcription initiation and antigenic variation

This study shows that TbRH2A is essential for resolving R-loops and preventing DNA damage in T. brucei, with distinct roles in RNA Pol II and Pol I transcription.