Author

C. Spahn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Research Focus:cell type annotation· 3 Assay:imaging· 3 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Assay:cryo-EM· 1

Frequent Co-Authors

M. Heilemann· 3 shared E. Gomez-de-Mariscal· 2 shared R. Henriques· 2 shared S. Holden· 2 shared A. Balke· 1 shared A. Diepold· 1 shared B. Qin· 1 shared C. Vieira-Vieira· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

M. Heilemann

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Yersinia actively downregulates type III secretion and adhesion at higher cell densities

F. Ermoli, G. Malengo, C. Spahn, T. Glatter, A. Diepold

This study shows Yersinia enterocolitica suppresses T3SS expression and adhesion at high cell densities through VirF downregulation and CsrBC-mediated mechanisms.

bioRxiv · Jun 27, 2024Microbiology

Transertion and cell geometry organize the Escherichia coli nucleoid during rapid growth

C. Spahn, S. Middlemiss, E. Gomez-de-Mariscal, R. Henriques, H. B. Bode, S. Holden, M. Heilemann

This study shows that transertion and cell geometry influence the spatial organization of the E. coli nucleoid during growth and antibiotic treatment.

bioRxiv · Oct 16, 2023 · PreprintMicrobiology

Time-resolved cryo-EM reveals early ribosome assembly in action

B. Qin, S. M. Lauer, A. Balke, C. Vieira-Vieira, J. Buerger, T. Mielke, M. Selbach, P. Scheerer, C. Spahn, R. Nikolay

The paper uses time-resolved cryo-EM to study early ribosome assembly in bacteria, revealing domain-wise and incremental assembly mechanisms and cooperative rRNA folding.

bioRxiv · Nov 12, 2022Biophysics

DeepBacs: Bacterial image analysis using open-source deep learning approaches

C. Spahn, R. F. Laine, P. M. Pereira, E. Gomez-de-Mariscal, L. von Chamier, M. Conduit, M. G. Pinho, S. Holden, G. Jacquemet, M. Heilemann, R. Henriques

DeepBacs uses open-source deep learning to analyze bacterial microscopy images, offering tools for segmentation, classification, and phenotyping with applications in antibiotic research.

bioRxiv · Nov 3, 2021Microbiology

Bleaching-independent, whole-cell, 3D and multi-color STED imaging with exchangeable fluorophores

C. Spahn, J. B. Grimm, L. D. Lavis, M. Lampe, M. Heilemann

The paper introduces a bleaching-independent STED microscopy method using exchangeable fluorophores, enabling long-term whole-cell 3D and multi-color imaging in live cells.

bioRxiv · Sep 18, 2018Biophysics