B. Qin

Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancer

This study identifies MMP1+ fibroblasts as a cellular determinant of resistance to PD-1 pathway blockade in NSCLC by analyzing single-cell RNA sequencing data and spatial architecture.

Selective dissociation of vacant 70S ribosomes by RsfS promotes bacterial adaptation to nutrient starvation

This study shows RsfS selectively dissociates vacant 70S ribosomes during nutrient starvation, improving bacterial survival by conserving energy.

Lactylation-driven FTO-mediated m6A modification of CDK2 aggravates diabetic microvascular anomalies

This study shows that FTO, through lactylation-driven m6A modification of CDK2, worsens diabetic retinopathy by promoting angiogenesis and inflammation, and presents a nanotherapeutic approach to inhibit FTO.

Plastome-based Phylogenomic analyses provide insights into the germplasm resource diversity of Cibotium in China

This study uses plastome data to analyze the genetic diversity and phylogeny of Cibotium species in China, identifying cryptic species and lineage differentiation to aid conservation and breeding efforts.

Time-resolved cryo-EM reveals early ribosome assembly in action

The paper uses time-resolved cryo-EM to study early ribosome assembly in bacteria, revealing domain-wise and incremental assembly mechanisms and cooperative rRNA folding.

Quorum-sensing- and type VI secretion-mediated spatio-temporal cell death drives genetic diversity in Vibrio cholerae

This study shows that T6SS-mediated cell death in V. cholerae colonies drives genetic diversity through quorum-sensing-controlled spatio-temporal phases of cell death.

Quorum-sensing control of matrix protein production drives fractal wrinkling and interfacial localization of Vibrio cholerae pellicles

Measuring drift by mean deviation: unequal breeding sex ratio revisited

This paper introduces mean deviation of allele frequency change as a new measure of genetic drift and tests it in an unequal breeding sex ratio scenario.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Measuring drift by mean deviation: unequal breeding sex ratio revisited

The paper introduces NN-LMM, a method that improves genomic prediction by integrating intermediate omics data through multi-layer neural networks, showing better performance than existing single-step approaches.

Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis

This paper identifies a small molecule agonist of Mtb adenylyl cyclase Rv1625c that inhibits cholesterol utilization and disrupts Mtb pathogenesis in mice.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

Acrylamide Fragment Inhibitors that Induce Unprecedented Conformational Distortions in Enterovirus 71 3C and SARS-CoV-2 Main Protease

The paper identifies acrylamide fragments that covalently inhibit EV71 3Cpro and SARS-CoV-2 Mpro by targeting their active site cysteine, inducing conformational changes and allosteric effects.

Mechanism of duplex unwinding by coronavirus nsp13 helicases

This paper investigates the unwinding mechanism of coronavirus nsp13 helicases using single-molecule FRET, revealing distinct step sizes and NTP hydrolysis patterns between MERS-CoV and SARS-CoV-2 nsp13.

Binding of the SARS-CoV-2 Spike Protein to Glycans

This study compares the binding of SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins to glycans, finding HS binding is sulfation-dependent and sialic acid binding is absent.