C. V. Maduka

This study modulates the inflammatory response to PLA-HA biomaterials by targeting immunometabolism, reducing proinflammatory cells and increasing pro-regenerative ones.

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

The paper identifies flavinated SDHA as responsible for altered autofluorescence in oral cancer cells, linking it to metabolic changes and potential diagnostic and therapeutic targets.

This study shows that PLA stereochemistry affects immune responses through differential metabolic changes in macrophages and fibroblasts, with stereocomplex PLA increasing proinflammatory cytokines via glycolysis.

The paper shows that elevated oxidative phosphorylation in macrophages exposed to polyethylene particles increases ROS and proinflammatory cytokines, suggesting a role in inflammation and implant failure.

The paper shows that polyethylene particles alter immune cell metabolism, leading to glycolytic reprogramming and inflammation, which can be inhibited to promote bone integration.

This study shows that PLA degradation products reprogram cell metabolism, leading to immune activation and inflammation, and demonstrates that targeting metabolism can reduce inflammation and improve biocompatibility.