C. H. Contag

This study demonstrates targeted intracellular delivery of molecular cargo to hypoxic breast cancer stem cells using GlaS, a protein that binds phosphatidylserine and delivers payloads under hypoxic conditions.

This study modulates the inflammatory response to PLA-HA biomaterials by targeting immunometabolism, reducing proinflammatory cells and increasing pro-regenerative ones.

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

The paper identifies flavinated SDHA as responsible for altered autofluorescence in oral cancer cells, linking it to metabolic changes and potential diagnostic and therapeutic targets.

This paper develops a biodegradable bioactive glass-based humidity sensor that detects hydration changes, useful for monitoring brain edema and intracranial pressure.

This study shows that PLA stereochemistry affects immune responses through differential metabolic changes in macrophages and fibroblasts, with stereocomplex PLA increasing proinflammatory cytokines via glycolysis.

The paper shows that elevated oxidative phosphorylation in macrophages exposed to polyethylene particles increases ROS and proinflammatory cytokines, suggesting a role in inflammation and implant failure.

The paper shows that polyethylene particles alter immune cell metabolism, leading to glycolytic reprogramming and inflammation, which can be inhibited to promote bone integration.

This study shows that PLA degradation products reprogram cell metabolism, leading to immune activation and inflammation, and demonstrates that targeting metabolism can reduce inflammation and improve biocompatibility.

This study uses superparamagnetic iron oxide nanoparticles and alternating magnetic fields to control temperature-sensitive repressors in Bacillus subtilis, demonstrating magnetothermal regulation of gene expression.

This paper describes a GLA-domain that binds externalized phosphatidylserine and enables rapid, energy-independent intracellular delivery of probes in animal models.

This paper uses insect olfactory neural circuits to detect human oral cancers by analyzing VOCs from cell cultures, achieving fast and reliable classification.

The paper improves magnetic particle imaging by modifying magnetosome structures in magnetotactic bacteria, resulting in enhanced MPI signals and resolution.

This study develops a new bioink, GelMA-Ag-BaG, for 3D bioprinting of bone-like constructs, showing improved homogeneity, rheology, and degradation compared to existing materials.

This study uses Magnetic Particle Imaging to track iron-labeled tumor cells in vivo, revealing their movement and accumulation, and confirms their presence in tissues through histology.

This paper develops engineered endosymbionts that direct mammalian gene expression by secreting transcription factors into the host cell nucleus.