R. Narayan

Regulating the proinflammatory response to implanted composite biomaterials comprising polylactide and hydroxyapatite by targeting immunometabolism

This study modulates the inflammatory response to PLA-HA biomaterials by targeting immunometabolism, reducing proinflammatory cells and increasing pro-regenerative ones.

Immunometabolic cues recompose and reprogram the microenvironment around biomaterials

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

SARS-CoV-2 variants exhibit differential gut tropism and dysbiosis in Syrian golden hamsters.

This study examines SARS-CoV-2 variants' gut tropism and impact on gut microbiota in Syrian golden hamsters, finding Delta's stronger gastrointestinal preference and greater microbial dysbiosis.

Stereochemistry Determines Immune Cellular Responses to Polylactide Implants

This study shows that PLA stereochemistry affects immune responses through differential metabolic changes in macrophages and fibroblasts, with stereocomplex PLA increasing proinflammatory cytokines via glycolysis.

Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming

This study shows that PLA degradation products reprogram cell metabolism, leading to immune activation and inflammation, and demonstrates that targeting metabolism can reduce inflammation and improve biocompatibility.

ORF6 protein of SARS-CoV-2 inhibits TRIM25 mediated RIG-I ubiquitination to mitigate type I IFN induction.

This study identifies ORF6 as a SARS-CoV-2 protein that inhibits TRIM25-mediated RIG-I ubiquitination, thereby blocking type I IFN induction and signaling.

A natural broad-spectrum inhibitor of enveloped virus entry, effective against SARS-CoV-2 and Influenza A Virus in preclinical animal models.

This paper identifies picolinic acid as a broad-spectrum antiviral that inhibits enveloped virus entry, showing efficacy against SARS-CoV-2 and Influenza A Virus in animal models.

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

This study identifies montelukast sodium hydrate as a potential antiviral drug against SARS-CoV-2 by targeting the Nsp1-ribosomal complex and reducing viral replication in cell cultures.

Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples

This study identifies prognostic markers and therapeutic targets for COVID-19 by analyzing Omics data from nasal and BALF samples, finding S100 family genes and TXN as key factors, and validating Auranofin as a potential treatment.

Non-oncology drugs are a source of previously unappreciated anti-cancer activity

The paper identifies non-oncology drugs with anti-cancer activity across 578 cancer cell lines using PRISM, finding that many drugs selectively inhibit cancer cells based on molecular features.