A. Tundo

Magnetic particle imaging reveals that iron-labeled extracellular vesicles accumulate in brains of mice with metastases

This paper uses magnetic particle imaging to show that iron-labeled extracellular vesicles accumulate in brains of mice with brain metastases but not in mice without metastases.

Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells

This study demonstrates targeted intracellular delivery of molecular cargo to hypoxic breast cancer stem cells using GlaS, a protein that binds phosphatidylserine and delivers payloads under hypoxic conditions.

Regulating the proinflammatory response to implanted composite biomaterials comprising polylactide and hydroxyapatite by targeting immunometabolism

This study modulates the inflammatory response to PLA-HA biomaterials by targeting immunometabolism, reducing proinflammatory cells and increasing pro-regenerative ones.

Immunometabolic cues recompose and reprogram the microenvironment around biomaterials

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

Elevated oxidative phosphorylation is critical for immune cell activation by polyethylene wear particles

The paper shows that elevated oxidative phosphorylation in macrophages exposed to polyethylene particles increases ROS and proinflammatory cytokines, suggesting a role in inflammation and implant failure.

Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming

This study shows that PLA degradation products reprogram cell metabolism, leading to immune activation and inflammation, and demonstrates that targeting metabolism can reduce inflammation and improve biocompatibility.