Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation
S. S. Dhar, C. Brown, A. Rizvi, L. Reed, S. Kotla, C. Zod, J. Abraham, J.-I. Abe, V. Rajaram, K. Chen, M. Lee
This study shows that heterozygous Kmt2d loss promotes medulloblastoma by enhancing tumor-promoting programs and that combining LSD1 inhibition with oxidative phosphorylation blockade reduces tumorigenicity.
bioRxiv · Oct 29, 2023 · PreprintCancer Biology