CDK8/19 Inhibition Attenuates G1 Arrest Induced by BCR-ABL Antagonists and Accelerates Death of Chronic Myelogenous Leukemia Cells
A. I. Khamidullina, M. A. Yastrebova, A. V. Bruter, J. V. Nuzhina, N. E. Vorobyeva, A. M. Khrustaleva, E. A. Varlamova, A. V. Tyakht, Y. E. Abramenko, E. S. Ivanova, M. A. Zamkova, J. Li, C.-U. Lim, M. Chen, E. V. Broude, , V. V. Tatarskiy
This study shows that CDK8/19 inhibition overcomes BCR-ABL inhibitor-induced G1 arrest and promotes apoptosis in CML cells.
Cell Death Discovery · Feb 15, 2025Peer-reviewedCancer Biology