Y. Pu

Machine learning on multiple epigenetic features reveals H3K27Ac as a driver of gene expression prediction across patients with glioblastoma.

Cyclic di-GMP as an Antitoxin Regulates Bacterial Genome Stability and Antibiotic Persistence in Biofilms

The paper identifies a toxin-antitoxin system in biofilms where c-di-GMP regulates genome stability and antibiotic persistence by controlling HipH activity.

Aggresomes protect mRNA under stress in Escherichia coli

The paper shows that aggresomes in E. coli store mRNA under stress, aiding rapid recovery by protecting mRNA from degradation and facilitating translation reactivation.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

Electrostatically regulated active site assembly governs reactivity in non-heme iron halogenases

This study investigates how anion and substrate binding cooperatively regulate reactivity in non-heme iron halogenases through electrostatic interactions in the active site.

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

Brassinosteroids modulate autophagy through phosphorylation of RAPTOR1B by the GSK3-like kinase BIN2 in Arabidopsis

This study shows that brassinosteroids modulate autophagy in Arabidopsis by phosphorylating RAPTOR1B via BIN2 kinase, linking BR signaling to TOR-mediated autophagy regulation.

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection

This study identifies halofuginone as a potent inhibitor of SARS-CoV-2 infection and replication by reducing heparan sulfate biosynthesis and suppressing viral replication.

Quantitative proteomics reveals extensive lysine ubiquitination in the Arabidopsis root proteome and uncovers novel transcription factor stability states

This study identifies 3,178 ubiquitinated proteins in Arabidopsis roots using a diGly enrichment method, revealing novel transcription factor stability regulation.

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

This study shows SARS-CoV-2 spike protein binds to heparan sulfate and ACE2 on cells codependently, forming a complex that facilitates infection, suggesting potential therapeutic targets.

Functional Landscape of SARS-CoV-2 Cellular Restriction

This study identifies key interferon stimulated genes (ISGs) that restrict SARS-CoV-2 infection by inhibiting viral entry, RNA synthesis, and release.

Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

Escherichia coli’s physiology can turn membrane voltage dyes into actuators

The paper develops a workflow to characterize Nernstian membrane voltage dyes in E. coli, identifying conditions where dyes act as actuators rather than probes.

Dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance

This study identifies dynamic protein aggregation as a regulator of bacterial dormancy depth, influencing antibiotic tolerance and resuscitation.