Author

Nathaniel J. Winsor

University of TorontoORCID 0000-0002-4984-3012Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Dana J. PhilpottiD· 2 shared Jessica K. BruceiD· 2 shared Stephen E. GirardiniD· 2 shared Adrienne RangeriD· 1 shared Christian Krustev· 1 shared Emily ForsteriD· 1 shared Herbert Y. GaisanoiD· 1 shared Jeffrey E. LeeiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

Dana J. PhilpottORCID

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2 papers

Recent·Most cited

Cell BiologyCommunications BiologyPeer-reviewedMay 12, 2025

GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium

Jessica K. Bruce, L Y Li, Yu Tang…·Stephen E. Girardin

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.

13 citations

humanmouse

𝕏 PostBluesky

ImmunologybioRxivPreprintJul 18, 2024

NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in the intestinal epithelium

Ryan J. Mazzone, Nathaniel J. Winsor, Lu Yi Li…·Stephen E. Girardin

This study shows that NLRP1B allele 2 in intestinal epithelial cells does not respond to VbP, unlike in macrophages, suggesting allele-dependent regulation in IECs.

DOI 10.1101/2024.07.18.604161

mouseproteomics

𝕏 PostBluesky