Author

D. A. Constant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

T. J. Nice· 4 shared J. A. Van Winkle· 3 shared A. P. Wright· 2 shared L. Li· 2 shared A. R. Gibson· 1 shared B. Ramirez Reyes· 1 shared C. Desai· 1 shared E. A. Kennedy· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersImmunology

T. J. Nice

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Author profile →

4 papers

Recent·Most cited

Interferon Regulatory Factor 6 Determines Intestinal Epithelial Cell Development and Immunity

A. P. Wright, S. Harris, S. R. Madden, B. Ramirez Reyes, E. Mulamula, A. R. Gibson, I. Rauch, D. A. Constant, T. J. Nice

This study identifies IRF6's role in regulating intestinal epithelial cell development and innate immunity, showing it modulates antiviral responses and maintains barrier function.

bioRxiv · Jan 4, 2024Immunology

Transcriptional and Cytotoxic Responses of Human Intestinal Organoids to Interferon Types I, II, and III

D. A. Constant, J. A. Van Winkle, E. VanderHoek, S. E. Dekker, M. A. Sofia, E. Regner, V. L. Tsikitis, N. Modiano, T. J. Nice

This study examines how human intestinal organoids respond to interferon types I, II, and III, revealing differences in transcriptional responses and cytotoxic effects.

bioRxiv · Dec 11, 2021 · PreprintImmunology

A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

J. A. Van Winkle, S. T. Peterson, E. A. Kennedy, M. J. Wheadon, H. Ingle, C. Desai, R. Rodgers, D. A. Constant, A. P. Wright, L. Li, M. Artyomov, S. Lee, M. T. Baldridge, T. J. Nice

The paper shows bacterial microbiota induce localized IFN-lambda-driven antiviral defenses in intestinal epithelial cells, enhancing host resistance to enteric viruses.

bioRxiv · Jun 2, 2021Immunology

Selective interferon responses of intestinal epithelial cells minimize TNFα cytotoxicity

J. A. Van Winkle, D. A. Constant, L. Li, T. J. Nice

This study shows that intestinal epithelial cells preferentially respond to type III IFN, leading to antiviral protection while minimizing TNFα-induced toxicity.

bioRxiv · Mar 20, 2020Immunology