Author

M. Artyomov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 11

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:mouse· 8 Research Focus:cell type annotation· 7 Research Focus:differential expression· 6 Research Focus:host-pathogen & immune response· 6 Assay:bulk RNA-seq· 4 Assay:scRNA-seq· 4 Approach:statistical model· 4

Frequent Co-Authors

A. Swain· 4 shared E. Esaulova· 3 shared D. Kaushal· 2 shared I. Shchukina· 2 shared M. Ahmed· 2 shared P. Andhey· 2 shared S. A. Khader· 2 shared S. Das· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersImmunology

A. Swain

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11 papers

Recent·Most cited

IL-15 priming alters IFN-γ regulation in murine NK cells

M. Cimpean, M. P. Keppel, A. Gainullina, C. Fan, N. C. Schedler, A. Swain, A. Kolicheski, H. Shapiro, H. A. Young, T. Wang, M. Artyomov, M. A. Cooper

This study shows that IL-15 priming changes IFN-γ regulation in murine NK cells by altering transcriptional responses to activating receptor stimulation.

bioRxiv · Apr 23, 2023Immunology

ATG5 suppresses type I IFN-dependent neutrophil swarming and NETosis

R. L. Kinsella, C. Sur Chowdhury, A. Smirnov, Y. Mreyoud, J. M. Kimmey, E. Esaulova, D. Kreamalmeyer, M. Artyomov, C. L. Stallings

This study shows that ATG5 suppresses type I IFN-induced neutrophil swarming and NETosis during M. tuberculosis infection, contributing to disease susceptibility when ATG5 is absent.

bioRxiv · Mar 18, 2023 · PreprintImmunology

Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction

M. E. Selli, J. H. Landmann, M. Terekhova, J. Lattin, A. Heard, Y.-S. Hsu, T.-C. Chang, J. M. Warrington, H. Ha, N. Kingston, G. Hogg, M. Slade, M. M. Berrien-Elliot, M. Foster, S. Kersting-Schadek, , N. Singh

This study identifies that chronic activation of 41BB-based CARs leads to a novel T cell dysfunction state, distinct from exhaustion, which can be mitigated by disrupting FOXO3.

bioRxiv · Jan 26, 2023 · PreprintImmunology

Single-cell RNA transcriptome analysis reveals CXCL16/CXCR6 as maintenance factors for CNS tissue resident T cells that drive synapse elimination during viral recovery

S. Rosen, A. L. Soung, W. Yang, S. Ai, M. Kanmogne, V. A. Dave, S. Prabhakar, A. Swain, M. Artyomov, J. A. Magee, R. S. Klein

bioRxiv · Oct 8, 2021 · PreprintImmunology

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

D. K. Singh, E. Aladyeva, S. Das, B. Singh, E. Esaulova, A. Swain, M. Ahmed, J. Cole, C. Moodley, S. Mehra, L. Schlesinger, M. Artyomov, S. A. Khader, D. Kaushal

This study uses longitudinal single-cell RNA sequencing in rhesus macaques to show that myeloid cell interferon responses correlate with SARS-CoV-2 clearance.

bioRxiv · Jun 28, 2021Immunology

Lung epithelial signaling mediates early vaccine-induced CD4+ T cell activation and Mtb control

S. Das, N. D. Marin, E. Esaulova, M. Ahmed, A. Swain, B. A. Rosa, M. Mitreva, J. Rangel-Moreno, M. Netea, L. B. Barreiro, M. Divangahi, M. Artyomov, D. Kaushal, S. A. Khader

This study identifies lung epithelial signaling as critical for early vaccine-induced CD4+ T cell activation and Mtb control in BCG vaccinated hosts.

bioRxiv · Jun 3, 2021Immunology

A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

J. A. Van Winkle, S. T. Peterson, E. A. Kennedy, M. J. Wheadon, H. Ingle, C. Desai, R. Rodgers, D. A. Constant, A. P. Wright, L. Li, M. Artyomov, S. Lee, M. T. Baldridge, T. J. Nice

The paper shows bacterial microbiota induce localized IFN-lambda-driven antiviral defenses in intestinal epithelial cells, enhancing host resistance to enteric viruses.

bioRxiv · Jun 2, 2021Immunology

A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

T. Lebratti, Y. S. Lim, A. Cofie, P. Andhey, X. Jiang, J. Scott, M. R. Fabbrizi, A. N. Ozantürk, C. Pham, R. Clemens, M. Artyomov, M. Dinauer, H. Shin

This study identifies a type I IFN-neutrophil-IL-18 axis driving immunopathology in genital HSV-2 infection.

bioRxiv · Dec 20, 2020Immunology

Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model

S. Ryu, I. Shchukina, Y.-H. Youm, H. Qing, B. K. Hilliard, T. Dlugos, X. Zhang, Y. Yasumoto, C. J. Booth, C. Fernandez-Hernando, Y. Suarez, K. M. Khanna, T. Horvath, M. O. Dietrich, M. Artyomov, , V. D. Dixit

This study shows that a ketogenic diet reduces inflammation and improves outcomes in aged mice infected with a coronavirus, suggesting potential therapeutic benefits for elderly COVID-19 patients.

bioRxiv · Sep 11, 2020 · PreprintImmunology

Dysregulation of adipose ILC2 underlies thermogenic failure in aging

E. L. Goldberg, I. Shchukina, Y.-H. Youm, C. D. Camell, T. Dlugos, M. Artyomov, V. D. Dixit

The paper identifies age-related changes in adipose tissue that reprogram ILC2, leading to impaired cold tolerance in aged mice.

bioRxiv · Sep 8, 2020 · PreprintImmunology

Toxoplasma gondii infection drives conversion of NK Cells into ILC1s

E. Park, S. Patel, Q. Wang, P. Andhey, K. Zaitsev, S. Porter, M. Hershey, M. Bern, B. Plougastel-Douglas, P. Collins, M. Colonna, K. M. Murphy, E. Oltz, M. Artyomov, L. D. Sibley, W. M. Yokoyama

This study shows Toxoplasma gondii infection converts NK cells into ILC1-like cells that persist and circulate independently of infection.

bioRxiv · May 17, 2019Immunology