Author

T. J. Nice

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Research Focus:differential expression· 3 Organism:human· 3

Frequent Co-Authors

D. A. Constant· 4 shared J. A. Van Winkle· 4 shared A. P. Wright· 2 shared L. Li· 2 shared M. T. Baldridge· 2 shared S. Lee· 2 shared A. M. Peters· 1 shared A. R. Gibson· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersImmunology

D. A. Constant

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Interferon Regulatory Factor 6 Determines Intestinal Epithelial Cell Development and Immunity

A. P. Wright, S. Harris, S. R. Madden, B. Ramirez Reyes, E. Mulamula, A. R. Gibson, I. Rauch, D. A. Constant, T. J. Nice

This study identifies IRF6's role in regulating intestinal epithelial cell development and innate immunity, showing it modulates antiviral responses and maintains barrier function.

bioRxiv · Jan 4, 2024Immunology

Transcriptional and Cytotoxic Responses of Human Intestinal Organoids to Interferon Types I, II, and III

D. A. Constant, J. A. Van Winkle, E. VanderHoek, S. E. Dekker, M. A. Sofia, E. Regner, V. L. Tsikitis, N. Modiano, T. J. Nice

This study examines how human intestinal organoids respond to interferon types I, II, and III, revealing differences in transcriptional responses and cytotoxic effects.

bioRxiv · Dec 11, 2021 · PreprintImmunology

A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

J. A. Van Winkle, S. T. Peterson, E. A. Kennedy, M. J. Wheadon, H. Ingle, C. Desai, R. Rodgers, D. A. Constant, A. P. Wright, L. Li, M. Artyomov, S. Lee, M. T. Baldridge, T. J. Nice

The paper shows bacterial microbiota induce localized IFN-lambda-driven antiviral defenses in intestinal epithelial cells, enhancing host resistance to enteric viruses.

bioRxiv · Jun 2, 2021Immunology

CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirus

V. R. Graziano, M. M. Alfajaro, C. Schmitz, R. B. Filler, M. S. Strine, J. Wei, L. L. Hsieh, M. T. Baldridge, T. J. Nice, S. Lee, R. C. Orchard, C. B. Wilen

This study uses a Cd300lf conditional knockout mouse to show that CD300lf on tuft cells is essential for persistent MNoVCR6 infection, while myelomonocytic cells are major targets for non-persistent MNoVCW3, with STAT1 restricting its tropism.

bioRxiv · Aug 19, 2020Microbiology

Selective interferon responses of intestinal epithelial cells minimize TNFα cytotoxicity

J. A. Van Winkle, D. A. Constant, L. Li, T. J. Nice

This study shows that intestinal epithelial cells preferentially respond to type III IFN, leading to antiviral protection while minimizing TNFα-induced toxicity.

bioRxiv · Mar 20, 2020Immunology

Myoviridae Phage PDX Kills Enteroaggregative Escherichia coli without Human Microbiome Dysbiosis

L. Cepko, E. Garling, M. Dinsdale, W. P. Scott, L. Bandy, J. Faber-Hammond, T. J. Nice, J. Mellies

This paper identifies a bacteriophage, PDX, that kills enteroaggregative Escherichia coli without disrupting the human microbiome, suggesting its potential as a therapeutic.

bioRxiv · Aug 26, 2019Microbiology

Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells

B. A. Robinson, J. A. Van Winkle, B. T. McCune, A. M. Peters, T. J. Nice

This study shows that cleavage of NS1/2 by caspases in MNV-infected intestinal epithelial cells promotes apoptosis and is required for persistent infection, but not for acute infection in other cell types.

bioRxiv · Mar 26, 2019Microbiology