Author

E. Sierecki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2 Microbiology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

Y. Gambin· 9 shared A. Bhumkar· 2 shared A. Tuckwell· 2 shared C. F. Dickson· 2 shared D. A. Jacques· 2 shared D. J. B. Hunter· 2 shared H. Venugopal· 2 shared A. Abendroth· 1 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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9 shared papersBiochemistry

Y. Gambin

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates

M. Uckelmann, V. Levina, C. Taveneau, X. H. Ng, V. Pandey, J. Martinez, S. Mendiratta, J. Houx, M. Boudes, H. Venugopal, S. Trepout, Q. Zhang, S. Flanigan, M. Li, E. Sierecki, , C. Davidovich

This study uses cryo-electron tomography to reveal that PRC1-CBX8 condensates are porous and dynamic, challenging the notion of rigid chromatin compaction in gene repression.

bioRxiv · May 8, 2023Biophysics

Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores

C. F. Dickson, S. Hertel, J. Ruan, N. Ariotti, A. Tuckwell, N. Li, S. Al-Izzi, E. Sierecki, Y. Gambin, R. G. Morris, G. J. Towers, T. Boecking, D. A. Jacques

This paper shows how the HIV capsid mimics karyopherins to penetrate nuclear pores by interacting with FG-motifs, enabling it to bypass the size limit of the nuclear pore complex.

bioRxiv · Mar 23, 2023 · PreprintBiochemistry

Selectivity of Protein Interactions along the Aggregation Pathway of a-Synuclein

A. Leitao, P. Rudolffi Soto, A. Chappard, A. Bhumkar, D. J. B. Hunter, E. Sierecki, Y. Gambin

This study maps protein interactions with different -SYN aggregation species, revealing selectivity in recruitment of LB components during aggregation.

bioRxiv · Jan 29, 2021Biochemistry

Rapid HIV-1 capsid interaction screening using fluorescence fluctuationspectroscopy

D. Lau, J. C. Walsh, C. F. Dickson, A. Tuckwell, J. H. Stear, D. J. B. Hunter, A. Bhumkar, V. Shah, S. G. Turville, E. Sierecki, Y. Gambin, D. A. Jacques, T. Böcking

This paper develops a fluorescence fluctuation spectroscopy method to rapidly screen HIV-1 capsid interactors by detecting binding events in solution.

bioRxiv · Nov 13, 2020Biophysics

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity.

A. J. McCann, J. Lou, M. Moustaqil, A. Blum, F. Fontaine, H. Liu, W. Luu, P. Koopman, E. Sierecki, Y. Gambin, F. A. Meunier, Z. Liu, E. Hinde, M. Francois

This study investigates how a dominant-negative SOX18 mutant disrupts transcription factor activity by interfering with chromatin-binding dynamics and recruiting the wild-type interactome.

bioRxiv · Nov 11, 2020Cell Biology

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential

B. Meyer, J. Chiaravalli, S. Gellenoncourt, P. Brownridge, D. P. Bryne, L. A. Daly, A. Grauslys, M. Walter, F. Agou, L. A. Chakrabarti, C. S. Craik, C. E. Eyers, P. A. Eyers, Y. Gambin, A. R. Jones, , E. Emmott

This study identifies novel SARS-CoV-2 protease cleavage sites and cellular targets using mass spectrometry, showing that targeting these proteins can inhibit viral replication.

bioRxiv · Sep 16, 2020Microbiology

Cavin3 released from caveolae interacts with BRCA1to regulate the cellular stress response

R. G. Parton, K.-A. McMahon, D. A. Stroud, Y. Gambin, V. Tillu, M. Bastiani, E. Sierecki, M. Polinkovsky, T. E. Hall, G. A. Gomez, Y. Wu, M.-O. Parat, N. Martel, H. P. Lo, K. k. Khanna, , M. Ryan

This study shows cavin3 interacts with BRCA1 to regulate DNA repair and cellular stress response, with implications for cancer.

bioRxiv · Jul 26, 2020Cancer Biology

Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death

M. Steain, M. O. D. G. Baker, C. L. L. Pham, Y. Gambin, E. Sierecki, B. P. McSharry, S. Avdic, B. Slobedman, M. Sunde, A. Abendroth

This paper identifies a viral RHIM in VZV ORF20 that forms amyloid complexes with ZBP1 to inhibit apoptosis during infection.

bioRxiv · Mar 12, 2020Microbiology

The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification.

S. S. Pang, C. Bayly-Jones, M. Radjainia, B. A. Spicer, R. H. P. Law, A. W. Hodel, S. M. Ekkel, P. J. Conroy, G. Ramm, H. Venugopal, P. I. Bird, B. W. Hoogenboom, I. Voskoboinik, Y. Gambin, E. Sierecki, , J. C. Whisstock

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.

bioRxiv · Mar 17, 2019 · PreprintBiochemistry