M. Chandra

VARP binds SNX27 to promote endosomal supercomplex formation on membranes

This study identifies VARP's role in forming endosomal supercomplexes with SNX27 and Retromer through direct interaction and biochemical reconstitution.

Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor Therapy

The paper maps treatment-associated changes in the tumor immune microenvironment using single-cell RNA sequencing and identifies transition patterns that predict response to checkpoint inhibitor therapy.

A Structural Classification of the Variant Surface Glycoproteins of the African Trypanosome

The paper uses experimental and computational methods to classify VSG proteins in African trypanosomes, revealing structural and conformational diversity that contributes to immune evasion.

Structural and Immunological Similarities Between the Metacyclic and Bloodstream Form Variant Surface Glycoproteins of the African Trypanosome

This study shows metacyclic and bloodstream form VSGs of African trypanosomes are structurally and immunologically similar.

Improved mammalian retromer cryo-EM structures reveal a new assembly interface

The paper improves mammalian retromer cryo-EM structures, revealing a new assembly interface between VPS26A and VPS35 N-termini.

Drosophila Snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes

This study identifies Snazarus as a regulator of lipid droplet organization in Drosophila adipocytes, showing its role in maintaining peripheral lipid droplets at plasma membrane contacts.