D. B. Lacy

Inhibition of EGFR/ErbB does not protect against C. difficile toxin B

This study investigates whether inhibiting EGFR/ErbB receptors protects against C. difficile toxin B, finding no protective effect.

Paeniclostridium sordellii NanS works synergistically with TcsL to increase cytotoxicity and the severity of pathogenesis in the murine uterus

This study shows that NanS and TcsL work together to increase cytotoxicity and disease severity in a mouse uterine infection model.

Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo

This paper develops nanobodies against C. difficile toxins TcdA and TcdB, identifies neutralizing epitopes, and creates assays for in vivo toxin quantitation.

Toxin-mediated downregulation of absorptive ion transporters NHE3, DRA, and SGLT1 in the colon contributes to diarrhea associated with Clostridioides difficile infection.

This study shows CDI reduces NHE3, DRA, and SGLT1 in the colon, impairing ion transport and causing osmotic diarrhea.

Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection

This study investigates the role of glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins TcdA and TcdB during infection, showing both contribute to disease with distinct pathological outcomes.

Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS

The paper uses cryo-EM to determine the structure of the Legionella pneumophila Dot/Icm T4SS, identifying new proteins and symmetry elements that contribute to its function.

Murine intrarectal instillation of purified recombinant C. difficile toxins enables mechanistic studies of pathogenesis

This study uses purified recombinant C. difficile toxins in a mouse model to investigate their pathogenic mechanisms and tissue effects.