Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity
E. Olmedillas, C. J. Mann, W. Peng, Y.-T. Wang, R. Diaz Avalos, D. Bedinger, K. Valentine, N. Shafee, S. L. Schendel, M. Yuan, G. Lang, R. Rouet, D. Christ, W. Jiang, I. A. Wilson, , E. Ollmann Saphire
This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.
bioRxiv · May 6, 2021 · PreprintMicrobiology