The central nervous system is a potential reservoir and possible origin of drug resistance in HBV
L. Xu, M. Zhou, X. Peng, Y. Xu, F. Huang, L. Wang, x. peng, Z. Yang, R. Tao, G. Lang, Q. Cao, M. Li, Y. Huang, B. Zhu, Y. Xu
This study finds HBV can persist in cerebrospinal fluid, showing distinct mutations and resistance patterns compared to serum, and HIV co-infection increases resistance mutations in both compartments.
bioRxiv · Apr 5, 2023 · PreprintEvolutionary Biology