Author

C. J. Mann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

I. A. Wilson· 2 shared L. He· 2 shared A. B. Ward· 1 shared A. Coscia· 1 shared A. Sarkar· 1 shared C.-K. Kwok· 1 shared D. Bedinger· 1 shared D. Christ· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

I. A. Wilson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural basis for VLDLR recognition by eastern equine encephalitis virus

P. Yang, W. Li, X. Fan, J. Pan, C. J. Mann, H. Varnum, L. E. Clark, S. A. Clark, A. Coscia, K. N. Smith, V. Brusic, J. Abraham

This study determines the structures of EEEV and SFV spike glycoproteins bound to VLDLR, revealing distinct binding modes that explain how different alphaviruses use the same receptor.

bioRxiv · Nov 14, 2023Microbiology

Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity

E. Olmedillas, C. J. Mann, W. Peng, Y.-T. Wang, R. Diaz Avalos, D. Bedinger, K. Valentine, N. Shafee, S. L. Schendel, M. Yuan, G. Lang, R. Rouet, D. Christ, W. Jiang, I. A. Wilson, , E. Ollmann Saphire

This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.

bioRxiv · May 6, 2021 · PreprintMicrobiology

mRNA translation control by Dhx36 binding to 5' UTR G-quadruplex structures is essential for skeletal muscle stem cell regenerative functions

X. Chen, J. Yuan, G. Xue, S. Campanario Sanz, D. Wang, W. Wang, X. Mou, M. I. I. Umar, J. Isern, Y. Zhao, L. He, Y. Li, C. J. Mann, X. Yu, L. Wang, , H. Wang

This study identifies Dhx36 as essential for skeletal muscle stem cell regeneration by regulating mRNA translation through binding and unwinding 5' UTR G-quadruplex structures.

bioRxiv · Aug 30, 2020Cell Biology

HIV-1 vaccine design through minimizing envelope metastability

L. He, S. Kumar, J. J. Allen, D. Huang, X. Lin, C. J. Mann, K. L. Saye-Francisco, J. Copps, A. Sarkar, G. S. Blizard, G. Ozorowski, D. Sok, M. Crispin, A. B. Ward, D. Nemazee, , J. Zhu

This paper demonstrates that gp41ECTO is the main source of HIV-1 envelope metastability and shows that stabilizing it improves nanoparticle assembly and induces more effective tier 2 neutralizing antibodies.

bioRxiv · Jul 4, 2018Microbiology