A conserved role of the insulin-like signaling pathway in uric acid pathologies revealed in Drosophila melanogaster
S. Lang, N. Bose, K. Wilson, D. Brackman, T. Hilsabeck, M. Watson, J. Beck, A. Sharma, L. Chen, D. Killilea, S. Ho, A. Kahn, K. Giacomini, M. Stoller, T. Chi, P. Kapahi
This study shows that the insulin-like signaling pathway influences uric acid metabolism in Drosophila, with conserved effects in humans, and identifies potential therapeutic targets for gout and kidney stones.
PLOS Genetics · Aug 15, 2019Peer-reviewedPathology