T. Chi

Environmental and Historical Determinants of African Horse Sickness: Insights from Predictive Modeling

This study uses predictive modeling to analyze global patterns of African Horse Sickness, identifying high-risk areas and highlighting the impact of climate on disease transmission.

CZ CELLxGENE Discover: A single-cell data platform for scalable exploration, analysis and modeling of aggregated data

CZ CELLxGENE Discover provides a platform for scalable exploration and analysis of aggregated single-cell transcriptomic data across multiple studies.

Benzo(a)pyrene regulates chaperone-mediated autophagy via heat shock protein 90

This study shows that benzo(a)pyrene induces chaperone-mediated autophagy (CMA) and DNA damage through heat shock protein 90 (HSP90) in lung cells.

IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors

This study shows that knocking out IKZF3 in CAR T cells enhances their ability to kill solid tumor cells in vitro and in xenograft models.

Sex-specific predictive values of biomarkers for immunotherapy efficacy in lung adenocarcinoma

This study identifies sex-specific differences in the predictive power of biomarkers for anti-PD-1 immunotherapy efficacy in lung adenocarcinoma, highlighting the need to consider sex when using conventional biomarkers.

Sex-based mutational landscape confers sensitivity to checkpoint blockade immunotherapy in cutaneous melanoma

The paper investigates sex-based differences in the mutational landscape of cutaneous melanoma and their impact on response to anti-PD-1 immunotherapy, finding that high tumor mutation burden correlates with immunotherapeutic response only in males.

A reversible KO model reveals therapeutic 1 potentials of defective Tregs

The paper uses a reversible KO model to show that restoring Brg1 in defective Tregs can convert them into potent SuperTregs, rescuing inflammation and suggesting a therapeutic strategy for IPEX-related disorders.

A conserved role of the insulin-like signaling pathway in uric acid pathologies revealed in Drosophila melanogaster

This study shows that the insulin-like signaling pathway influences uric acid metabolism in Drosophila, with conserved effects in humans, and identifies potential therapeutic targets for gout and kidney stones.