CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer
J. Li, T. A. Hilimire, Y. Liu, L. Wang, J. Liang, B. Gyorffy, V. Sikirzhytski, H. Ji, L. Zhang, C. Cheng, X. Ding, K. R. Kerr, C. E. Dowling, A. A. Chumanevich, G. P. Schools, , M. Chen
This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.
bioRxiv · Aug 8, 2023Cancer Biology