Author

D. Carling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Tomas· 2 shared B. Jones· 2 shared E. R. McGlone· 2 shared S. R. Bloom· 2 shared T. M. Tan· 2 shared A. Benito· 1 shared A. E. Pollard· 1 shared A. Inoue· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Tomas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pharmacological AMP-activated protein kinase activation suppresses low glucose-dependent macrophage migration inhibitory factor release from macrophages

J. Zhang, A. E. Pollard, D. Carling, V. Benoit, K. L. Ellacott, C. Beall

This study shows that activating AMPK reduces MIF release from macrophages under low glucose conditions by inhibiting NFB signaling.

bioRxiv · Oct 16, 2023 · PreprintPharmacology & Toxicology

Hepatocyte cholesterol content modulates glucagon receptor signalling

E. R. McGlone, T. B. Ansell, C. Dunsterville, W. Song, D. Carling, A. Tomas, S. R. Bloom, M. Sansom, T. M. Tan, B. Jones

This study shows that hepatocyte cholesterol content affects glucagon receptor signaling, with higher cholesterol reducing glucagon's ability to lower blood sugar in NAFLD.

bioRxiv · Oct 31, 2021Pharmacology & Toxicology

Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

E. R. McGlone, Y. Manchanda, B. Jones, P. Pickford, A. Inoue, D. Carling, S. R. Bloom, T. M. Tan, A. Tomas

This study investigates how RAMP2 affects GCGR trafficking and signaling in hepatocytes, showing it alters receptor internalization and signaling bias with limited metabolic impact.

bioRxiv · May 9, 2021Cell Biology

Indisulam targets RNA splicing and metabolism to serve as a novel therapeutic strategy for high-risk neuroblastoma

A. Nijhuis, A. Sikka, O. Yogev, L. Herendi, C. Eckold, G. Valbuena, Y. Liu, E. Kouloura, E. Poon, B. Martins da Costa, A. Benito, H. Kramer, A. Montoya, D. Carling, E. J. Want, , H. C. Keun

This study shows that indisulam, a sulphonamide, targets RNA splicing and metabolism to inhibit neuroblastoma growth and achieve complete tumor remission in preclinical models.

bioRxiv · Dec 18, 2020Cancer Biology