Author

A. Montoya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2

Frequent Co-Authors

H. Kramer· 4 shared A. Benito· 1 shared A. J. Donnelly· 1 shared A. Khammanivong· 1 shared A. Llauro· 1 shared A. Marta· 1 shared A. Nijhuis· 1 shared A. Osakwe· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersCell Biology

H. Kramer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

V. Yu, F. Yong, A. Marta, S. Khadayate, A. Osakwe, S. Bhattacharya, S. S. Varghese, P. Chabosseau, S. M. Tabibi, K. Chen, E. Georgiadou, N. Parveen, M. Suleiman, Z. Stamoulis, L. Marselli, , S. J. Millership

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

bioRxiv · Feb 4, 2023Cell Biology

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

K. Makielski, A. J. Donnelly, A. Khammanivong, M. C. Scott, A. R. Ortiz, D. C. Galvan, H. Tomiyasu, C. Amaya, K. Ward, A. Montoya, J. R. Garbe, L. J. Mills, G. R. Cutter, J. M. Fenger, W. C. Kisseberth, , J. F. Modiano

The paper develops a gene signature using exosomal RNA from canine osteosarcoma xenografts and machine learning to detect residual disease in dogs, showing improved remission outcomes in validation samples.

Laboratory Investigation · Dec 1, 2021Peer-reviewedCancer Biology

Indisulam targets RNA splicing and metabolism to serve as a novel therapeutic strategy for high-risk neuroblastoma

A. Nijhuis, A. Sikka, O. Yogev, L. Herendi, C. Eckold, G. Valbuena, Y. Liu, E. Kouloura, E. Poon, B. Martins da Costa, A. Benito, H. Kramer, A. Montoya, D. Carling, E. J. Want, , H. C. Keun

This study shows that indisulam, a sulphonamide, targets RNA splicing and metabolism to inhibit neuroblastoma growth and achieve complete tumor remission in preclinical models.

bioRxiv · Dec 18, 2020Cancer Biology

A conserved activity for cohesin in bridging DNA molecules

P. Gutierrez-Escribano, M. Newton, A. Llauro, J. Huber, L. Tanasie, J. Davy, I. Aly, R. Aramayo, A. Montoya, H. Kramer, J. Stigler, D. Rueda, L. Aragon

This study identifies a conserved DNA bridging activity of cohesin complexes across species, revealing two bridge types with distinct force resistance and functional implications for cohesion and chromosome architecture.

bioRxiv · Sep 5, 2019 · PreprintBiochemistry

TRF1 prevents permissive DNA damage response, recombination and Break Induced Replication at telomeres

J.-B. Vannier, R. M. Porreca, P. P. Law, E. Herrera-Moyano, R. Gonzalez Franco, A. Montoya, P. Faull, H. Kramer

This study shows TRF1 prevents DNA damage response, recombination, and break-induced replication at telomeres by suppressing PML, BRCA1, and SMC5/6 complex accumulation.

bioRxiv · Jul 10, 2019 · PreprintCell Biology