H. Kramer

The intracellular bacterium Orientia tsutsugamushi hijacks the adaptor protein BICD2 for dynein-based motility

This study identifies how Orientia tsutsugamushi uses ScaC to recruit BICD2 for dynein-based motility, revealing a mechanism for bacterial transport within host cells.

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

Fic-mediated AMPylation tempers the Unfolded Protein Response during physiological stress

This study shows that Fic-mediated AMPylation regulates the UPR response in the pancreas during stress, preventing excessive inflammation and damage.

Diet suppresses tumour initiation by maintaining quiescence of mutation-bearing neural stem cells

This study shows that diet can suppress glioblastoma by restoring quiescence in p53-deficient neural stem cells through omega-3 fatty acids.

Snapshots of actin and tubulin folding inside the TRiC chaperonin

The paper captures structural snapshots of actin and tubulin folding within the TRiC chaperonin using cryo-EM, revealing how substrates interact with the chamber during folding.

Indisulam targets RNA splicing and metabolism to serve as a novel therapeutic strategy for high-risk neuroblastoma

This study shows that indisulam, a sulphonamide, targets RNA splicing and metabolism to inhibit neuroblastoma growth and achieve complete tumor remission in preclinical models.

Dissection-independent production of a protective whole-sporozoite malaria vaccine

A four-step process isolates pure malaria sporozoites from mosquitoes without manual dissection, enabling a whole-parasite vaccine that provides sterilizing protection.

A conserved activity for cohesin in bridging DNA molecules

This study identifies a conserved DNA bridging activity of cohesin complexes across species, revealing two bridge types with distinct force resistance and functional implications for cohesion and chromosome architecture.

Systematic identification of factors bound to isolated metaphase ESC chromosomes reveals a role for chromatin repressors in compaction

The paper identifies proteins bound to metaphase ESC chromosomes and shows chromatin repressors are involved in maintaining chromosome compaction.

Optical interrogation of sympathetic neuronal effects on macroscopic cardiac monolayer dynamics

This study uses optical methods to investigate how sympathetic neurons affect cardiac monolayer dynamics, focusing on neurotransmitter release, neuronal density effects, and optogenetics applications.

TRF1 prevents permissive DNA damage response, recombination and Break Induced Replication at telomeres

This study shows TRF1 prevents DNA damage response, recombination, and break-induced replication at telomeres by suppressing PML, BRCA1, and SMC5/6 complex accumulation.