Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells
J. A. Thoms, K. Knezevic, G. Harvey, Y. Huang, J. Seneviratne, D. R. Carter, S. Subramanian, J. Skhinas, D. Chacon, A. Shah, I. de Jong, D. Beck, B. Gottgens, J. Larsson, J. W. Wong, , J. E. Pimanda
The paper identifies a GATA2, TAL1, ERG regulatory circuit that promotes erythroid transition in both healthy and leukemic stem cells, showing its persistence in AML with minor alterations.
bioRxiv · Oct 26, 2020Cancer Biology