This study examines how different diets affect the jejunal microbiota of broiler chickens, finding that butyrate supplementation reduces Enterococcus faecium and Enterococcus hirae abundance in early development.

bioRxiv · Apr 5, 2023 · PreprintMicrobiology

Biliatresone treatment of pregnant mice causes changes in bile metabolism and liver inflammation in their offspring

K. Gupta, J. P. Xu, T. Diamond, I. de Jong, A. D. Glass, J. Llewellyn, N. D. Theise, J. D. Winkler, E. M. Behrens, C. Mesaros, R. G. Wells

This study shows that prenatal exposure to low-dose biliatresone in mice leads to altered bile metabolism and liver inflammation in offspring without histological damage.

bioRxiv · Mar 2, 2023 · PreprintPharmacology & Toxicology

Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

J. A. Thoms, K. Knezevic, G. Harvey, Y. Huang, J. Seneviratne, D. R. Carter, S. Subramanian, J. Skhinas, D. Chacon, A. Shah, I. de Jong, D. Beck, B. Gottgens, J. Larsson, J. W. Wong, , J. E. Pimanda

The paper identifies a GATA2, TAL1, ERG regulatory circuit that promotes erythroid transition in both healthy and leukemic stem cells, showing its persistence in AML with minor alterations.

bioRxiv · Oct 26, 2020Cancer Biology

A single-domain response regulator functions as integrating hub to coordinate general stress response and development in alpha-proteobacteria

C. Lori, A. Kaczmarczyk, I. de Jong, U. Jenal

This paper identifies MrrA as a central phosphorylation hub in Caulobacter crescentus that coordinates general stress response with development by acting as a phosphotransfer relay between multiple histidine kinases and response regulators.

bioRxiv · Apr 11, 2018Microbiology